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题名: Enantioseparation of tetrahydropalmatine and Troger's base by molecularly imprinted monolith in capillary electrochromatography
作者: Ou, Junjie;  Dong, Jing;  Tian, Tuijun;  Hu, Jiwei;  Ye, Mingliang;  Zou, Hanfa
关键词: tetrahydropalmatine ;  Troger's base ;  molecular imprinting polymer ;  capillary monolithic column ;  chiral separation ;  capillary electrochromatography
刊名: JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS
发表日期: 2007-02-23
DOI: 10.1016/j.jbbm.2006.07.003
卷: 70, 期:1, 页:71-76
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemical Research Methods ;  Biochemistry & Molecular Biology ;  Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ;  Biophysics
英文摘要: Two chiral compounds, Troger's base and tetrahydropalmatine, were enantioseparated on the (5S, 11S)-(-)-Troger's base and l-tetrahydropalmatine imprinted monolithic capillary columns with CEC, respectively. The monoliths were prepared by in situ thermal-initiated copolymerization of methacrylic acid (MAA) and ethylene dimethacrylate (EDMA). After optimizing the ratio of porogens (toluene and dodecanol), the obtained monolithic capillary columns show good flow-through property and enantioselectivity. The influences of CEC parameters such as pH of the buffer, organic solvent and salt concentration on the electroosmotic flow (EOF) and recognition selectivity were systematically investigated. Under the optimal conditions, baseline resolutions of two chiral compounds were achieved. In addition, the fast separation was obtained within 4 min by applying higher voltage and assisting pressure of 6 bar. (c) 2006 Elsevier B.V. All rights reserved.
关键词[WOS]: STATIONARY PHASES ;  DL-TETRAHYDROPALMATINE ;  LIQUID-CHROMATOGRAPHY ;  ENANTIOMER SEPARATION ;  CHIRAL SEPARATIONS ;  POLYMER-FILMS ;  COLUMN ;  SILICA ;  ELECTROPHORESIS ;  SELECTIVITY
语种: 英语
WOS记录号: WOS:000245001100010
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/140543
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R & A Ctr, Dalian 116023, Peoples R China

Recommended Citation:
Ou, Junjie,Dong, Jing,Tian, Tuijun,et al. Enantioseparation of tetrahydropalmatine and Troger's base by molecularly imprinted monolith in capillary electrochromatography[J]. JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS,2007,70(1):71-76.
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