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题名: Specific recognition of human telomeric G-quadruplex DNA with small molecules and the conformational analysis by ESI mass spectrometry and circular dichroism spectropolarimetry
作者: Zhou, Jiang;  Yuan, Gu
关键词: circular dichroism ;  DNA recognition ;  humna telometes ;  mass spectrometry ;  quadruplexes
刊名: CHEMISTRY-A EUROPEAN JOURNAL
发表日期: 2007
DOI: 10.1002/chem.200601605
卷: 13, 期:17, 页:5018-5023
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
英文摘要: Electrospray ionization mass spectrometry (ESI-MS) was utilized to investigate the binding affinity and stoichiometry of small molecules with human telomeric G-quadruplex DNA. The binding-affinity order obtained for the (AGGGTT)(4) quadruplex was: Te101 > ImImIm beta Dp >> PyPyPy gamma ImIm-Im beta Dp. The specific binding of Te101 and PyPyPy gamma ImImIm beta Dp in one system consisting of human telomeric G-quadruplex and duplex DNA was observed directly for the first time. This revealed that PyPyPy gamma ImImIm beta Dp has a binding specificity for the duplex DNA, whereas Te101 selectively recognizes the G-quadruplex DNA. Moreover, both ESI-MS and circular dichroism (CD) spectra indicated that Te101 favored the formation and stabilization of the antiparallel G-quadruplex, and a structural transition of the (AGGGTT)(4) sequence from a coexistence of parallel and antiparallel G-quadruplexes to a parallel G-quadruplex induced by annealing.
关键词[WOS]: DOUBLE-STRANDED OLIGODEOXYNUCLEOTIDES ;  NONCOVALENT COMPLEXES ;  POLYAMIDES ;  SELECTIVITY ;  AFFINITY ;  DRUGS ;  RNA
语种: 英语
WOS记录号: WOS:000247219900031
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/140587
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Dept Chem Biol,Coll Chem & Mol Engn, Beijing 100871, Peoples R China

Recommended Citation:
Zhou, Jiang,Yuan, Gu. Specific recognition of human telomeric G-quadruplex DNA with small molecules and the conformational analysis by ESI mass spectrometry and circular dichroism spectropolarimetry[J]. CHEMISTRY-A EUROPEAN JOURNAL,2007,13(17):5018-5023.
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