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题名: Diffusion of acetic acid across oil/water interface in emulsification-internal gelation process for preparation of alginate gel beads
作者: Xiu-dong, Liu;  Wei-ting, Yu;  Jun-zhang, Lin;  Xiao-jun, Ma;  Quan, Yuan
关键词: emulsification-internal gelation technology ;  alginate ;  gel bead ;  diffusion rate constant ;  diffusion coefficient
刊名: CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
发表日期: 2007-09-01
卷: 23, 期:5, 页:579-584
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
英文摘要: Alginate has been widely used in cell microencapsulation and drug delivery systems in the form of gel beads or microcapsules. Although an alternative novel emulsification-internal gelation technology has been established and both the properties and the potential applications of the beads in drug delivery systems have been studied, the mechanism has not been well understood compared with the traditional droplet method( external gelation technology). On the basis of our previous knowledge that the novel technology is composed of complicatedly consecutive processes with multistep diffusion and reaction, and the diffusion of acetic acid across oil/water interface being the prerequisite that determines the occurrence and rate for the reactions and the structures and properties of final produced gel beads, a special emphasis was placed on the diffusion process. With the aid of diffusion modeling and simple experimental design, the diffusion rate constant and diffusion coefficient of acetic acid across oil/water interface were determined to be in the orders of magnitude of 10(-6) and 10(-16), respectively. This knowledge will be of particular importance in understanding and interpreting the formation, structure of the gel beads and the relationship between the structure and properties and guiding the preparation and quality control of the gel beads.
关键词[WOS]: CALCIUM ALGINATE ;  CHITOSAN ;  MICROENCAPSULATION ;  MICROCAPSULES ;  MICROSPHERES ;  RELEASE ;  BEHAVIOR ;  DNA
语种: 英语
WOS记录号: WOS:000250324000021
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/140591
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
2.Dalian Univ, Coll Environm & Chem Engn, Dalian 116622, Peoples R China

Recommended Citation:
Xiu-dong, Liu,Wei-ting, Yu,Jun-zhang, Lin,et al. Diffusion of acetic acid across oil/water interface in emulsification-internal gelation process for preparation of alginate gel beads[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2007,23(5):579-584.
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