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题名: Inhibition of tumor growth in mice by endostatin derived from abdominal transplanted encapsulated cells
作者: Teng, Huaining;  Zhang, Ying;  Wang, Wei;  Ma, Xiaojun;  Fei, Jian
关键词: microencapsulation ;  endostatin ;  CHO ;  tumor ;  gene therapy
刊名: ACTA BIOCHIMICA ET BIOPHYSICA SINICA
发表日期: 2007-04-01
DOI: 10.1111/j.1745-7270.2007.00273.x
卷: 39, 期:4, 页:278-284
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemistry & Molecular Biology ;  Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ;  Biophysics
英文摘要: Endostatin, a C-terminal fragment of collagen 18a, inhibits the growth of established tumors and metastases in vivo by inhibiting angiogenesis. However, the purification procedures required for large-scale production and the attendant cost of these processes, together with the low effectiveness in clinical tests, suggest that alternative delivery methods might be required for efficient therapeutic use of endostatin. In the present study, we transfected Chinese hamster ovary (CHO) cells with a human endostatin gene expression vector and encapsulated the CHO cells in alginate-poly-L-lysine microcapsules. The release of biologically active endostatin was confirmed using the chicken chorioallantoic membrane assay. The encapsulated endostatin-expressing CHO cells can inhibit the growth of primary tumors in a subcutaneous B16 tumor model when injected into the abdominal cavity of mouse. These results widen the clinical application of the microencapsulated cell endostatin delivery system in cancer treatment.
关键词[WOS]: ANGIOGENESIS INHIBITOR ;  RECOMBINANT CELLS ;  GENE-THERAPY ;  ALGINATE ;  MICROENCAPSULATION ;  CANCER ;  IMMUNOSUPPRESSION ;  BIOCOMPATIBILITY ;  DELIVERY ;  BINDING
语种: 英语
WOS记录号: WOS:000245741000006
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/140636
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Model Organism Res Ctr,Lab Mol Cell Biol, Shanghai 200031, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
3.Second Mil Med Univ, Chengzheng Hosp, Dept Urol, Shanghai 200003, Peoples R China

Recommended Citation:
Teng, Huaining,Zhang, Ying,Wang, Wei,et al. Inhibition of tumor growth in mice by endostatin derived from abdominal transplanted encapsulated cells[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2007,39(4):278-284.
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