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题名: Rh-catalyzed asymmetric hydrogenation of gamma-phthalimido-substituted alpha,beta-unsaturated carboxylic acid esters: An efficient enantioselective synthesis of beta-aryl-gamma-amino acids
作者: Deng, Jun;  Duan, Zheng-Chao;  Huang, Jia-Di;  Hu, Xiang-Ping;  Wang, Dao-Yong;  Yu, Sai-Bo;  Xu, Xue-Feng;  Zheng, Zhuo
刊名: ORGANIC LETTERS
发表日期: 2007-11-08
DOI: 10.1021/ol702193v
卷: 9, 期:23, 页:4825-4828
收录类别: SCI ;  IC ;  CCR
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
英文摘要: A series of chiral beta-aryl-gamma-amino acid ester derivatives were synthesized in high enantioselectivities (93-97% ee) via the Rh-catalyzed asymmetric hydrogenation of gamma-phthalimido-alpha,beta-unsaturated carboxylic acid esters using highly modular chiral BoPhoz-type phosphine-aminophosphine ligands. The method has been applied successfully to the synthesis of several chiral pharmaceuticals including (R)-baclofen and (R)-rolipram with high enantioselectivities.
关键词[WOS]: C-H INSERTION ;  CONJUGATE ADDITION ;  STEREOSELECTIVE-SYNTHESIS ;  1,3-DICARBONYL COMPOUNDS ;  ANTIDEPRESSANT ROLIPRAM ;  LIGANDS ;  PEPTIDES ;  BACLOFEN ;  (-)-(R)-BACLOFEN ;  (R)-BACLOFEN
语种: 英语
WOS记录号: WOS:000250673000039
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/140682
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

Recommended Citation:
Deng, Jun,Duan, Zheng-Chao,Huang, Jia-Di,et al. Rh-catalyzed asymmetric hydrogenation of gamma-phthalimido-substituted alpha,beta-unsaturated carboxylic acid esters: An efficient enantioselective synthesis of beta-aryl-gamma-amino acids[J]. ORGANIC LETTERS,2007,9(23):4825-4828.
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