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Rh-catalyzed asymmetric hydrogenation of gamma-phthalimido-substituted alpha,beta-unsaturated carboxylic acid esters: An efficient enantioselective synthesis of beta-aryl-gamma-amino acids
Deng, Jun; Duan, Zheng-Chao; Huang, Jia-Di; Hu, Xiang-Ping; Wang, Dao-Yong; Yu, Sai-Bo; Xu, Xue-Feng; Zheng, Zhuo
刊名ORGANIC LETTERS
2007-11-08
DOI10.1021/ol702193v
9期:23页:4825-4828
收录类别SCI ; IC ; CCR
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]C-H INSERTION ; CONJUGATE ADDITION ; STEREOSELECTIVE-SYNTHESIS ; 1,3-DICARBONYL COMPOUNDS ; ANTIDEPRESSANT ROLIPRAM ; LIGANDS ; PEPTIDES ; BACLOFEN ; (-)-(R)-BACLOFEN ; (R)-BACLOFEN
英文摘要A series of chiral beta-aryl-gamma-amino acid ester derivatives were synthesized in high enantioselectivities (93-97% ee) via the Rh-catalyzed asymmetric hydrogenation of gamma-phthalimido-alpha,beta-unsaturated carboxylic acid esters using highly modular chiral BoPhoz-type phosphine-aminophosphine ligands. The method has been applied successfully to the synthesis of several chiral pharmaceuticals including (R)-baclofen and (R)-rolipram with high enantioselectivities.
语种英语
WOS记录号WOS:000250673000039
引用统计
被引频次:53[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/140682
专题中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式
GB/T 7714
Deng, Jun,Duan, Zheng-Chao,Huang, Jia-Di,et al. Rh-catalyzed asymmetric hydrogenation of gamma-phthalimido-substituted alpha,beta-unsaturated carboxylic acid esters: An efficient enantioselective synthesis of beta-aryl-gamma-amino acids[J]. ORGANIC LETTERS,2007,9(23):4825-4828.
APA Deng, Jun.,Duan, Zheng-Chao.,Huang, Jia-Di.,Hu, Xiang-Ping.,Wang, Dao-Yong.,...&Zheng, Zhuo.(2007).Rh-catalyzed asymmetric hydrogenation of gamma-phthalimido-substituted alpha,beta-unsaturated carboxylic acid esters: An efficient enantioselective synthesis of beta-aryl-gamma-amino acids.ORGANIC LETTERS,9(23),4825-4828.
MLA Deng, Jun,et al."Rh-catalyzed asymmetric hydrogenation of gamma-phthalimido-substituted alpha,beta-unsaturated carboxylic acid esters: An efficient enantioselective synthesis of beta-aryl-gamma-amino acids".ORGANIC LETTERS 9.23(2007):4825-4828.
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