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Lipoplex morphologies and their influences on transfection efficiency in gene delivery
Ma, Baichao; Zhang, Shubiao; Jiang, Huiming; Zhao, Budiao; Lv, Hongtao
关键词Lipoplex Morphology Gene Delivery Transfection Efficiency Cationic Lipoplexes
刊名JOURNAL OF CONTROLLED RELEASE
2007-11-20
DOI10.1016/j.jconrel.2007.08.022
123期:3页:184-194
收录类别SCI
文章类型Review
WOS标题词Science & Technology ; Physical Sciences ; Life Sciences & Biomedicine
类目[WOS]Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]LIPID-DNA COMPLEXES ; CATIONIC LIPOSOME COMPLEXES ; MEMBRANE CHARGE-DENSITY ; IN-VIVO TRANSFECTION ; PLASMID DNA ; GEMINI SURFACTANTS ; PHASE-BEHAVIOR ; LIPOFECTION EFFICIENCY ; CARCINOMA-CELLS ; HEXAGONAL PHASE
英文摘要Cationic lipid-mediated gene transfer is widely used for their advantages over viral gene transfer because it is non-immunogenic, easy to produce and not oncogenic. The main drawback of the application of cationic lipids is their low transfection efficiency. Many reports about transfection efficiency of cationic lipids have been published in recent years. In this review, the current status and prospects for transfection efficiency of different morphologies of lipoplexes are discussed. High transfection activity will be acquired for H(II)(C) structure when membrane fusion is dominant, but when serum is present L(alpha)(C), lipoplexes show great superiority for their inhibition dissociation by serum during lipoplexes transporting. Increasing DOPE often gains high activity for the H(II)(C) structure promoted by DOPE. High lipofection will be gained from large lipoplexes when endocytosis is dominant, because large particles facilitate membrane contact and fusion. We suggest morphologies of lipoplex should be characterized at two levels, lipoplex size and self-assemble structures of lipoplexes, and understanding these would be very important for scientists to prepare novel cationic lipids and design novel formulations with high transfection efficiency. (c) 2007 Elsevier B.V. All rights reserved.
语种英语
WOS记录号WOS:000251433500002
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被引频次:210[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/140690
专题中国科学院大连化学物理研究所
作者单位1.Dalian Natl Univ, SEAC, ME Key Lab Biotechnol & Bioresources Ulitiliz, Dalian 116600, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
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Ma, Baichao,Zhang, Shubiao,Jiang, Huiming,et al. Lipoplex morphologies and their influences on transfection efficiency in gene delivery[J]. JOURNAL OF CONTROLLED RELEASE,2007,123(3):184-194.
APA Ma, Baichao,Zhang, Shubiao,Jiang, Huiming,Zhao, Budiao,&Lv, Hongtao.(2007).Lipoplex morphologies and their influences on transfection efficiency in gene delivery.JOURNAL OF CONTROLLED RELEASE,123(3),184-194.
MLA Ma, Baichao,et al."Lipoplex morphologies and their influences on transfection efficiency in gene delivery".JOURNAL OF CONTROLLED RELEASE 123.3(2007):184-194.
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