中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
题名: Lipoplex morphologies and their influences on transfection efficiency in gene delivery
作者: Ma, Baichao;  Zhang, Shubiao;  Jiang, Huiming;  Zhao, Budiao;  Lv, Hongtao
关键词: lipoplex morphology ;  gene delivery ;  transfection efficiency ;  cationic lipoplexes
刊名: JOURNAL OF CONTROLLED RELEASE
发表日期: 2007-11-20
DOI: 10.1016/j.jconrel.2007.08.022
卷: 123, 期:3, 页:184-194
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology ;  Physical Sciences ;  Life Sciences & Biomedicine
类目[WOS]: Chemistry, Multidisciplinary ;  Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ;  Pharmacology & Pharmacy
英文摘要: Cationic lipid-mediated gene transfer is widely used for their advantages over viral gene transfer because it is non-immunogenic, easy to produce and not oncogenic. The main drawback of the application of cationic lipids is their low transfection efficiency. Many reports about transfection efficiency of cationic lipids have been published in recent years. In this review, the current status and prospects for transfection efficiency of different morphologies of lipoplexes are discussed. High transfection activity will be acquired for H(II)(C) structure when membrane fusion is dominant, but when serum is present L(alpha)(C), lipoplexes show great superiority for their inhibition dissociation by serum during lipoplexes transporting. Increasing DOPE often gains high activity for the H(II)(C) structure promoted by DOPE. High lipofection will be gained from large lipoplexes when endocytosis is dominant, because large particles facilitate membrane contact and fusion. We suggest morphologies of lipoplex should be characterized at two levels, lipoplex size and self-assemble structures of lipoplexes, and understanding these would be very important for scientists to prepare novel cationic lipids and design novel formulations with high transfection efficiency. (c) 2007 Elsevier B.V. All rights reserved.
关键词[WOS]: LIPID-DNA COMPLEXES ;  CATIONIC LIPOSOME COMPLEXES ;  MEMBRANE CHARGE-DENSITY ;  IN-VIVO TRANSFECTION ;  PLASMID DNA ;  GEMINI SURFACTANTS ;  PHASE-BEHAVIOR ;  LIPOFECTION EFFICIENCY ;  CARCINOMA-CELLS ;  HEXAGONAL PHASE
语种: 英语
WOS记录号: WOS:000251433500002
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/140690
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Dalian Natl Univ, SEAC, ME Key Lab Biotechnol & Bioresources Ulitiliz, Dalian 116600, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

Recommended Citation:
Ma, Baichao,Zhang, Shubiao,Jiang, Huiming,et al. Lipoplex morphologies and their influences on transfection efficiency in gene delivery[J]. JOURNAL OF CONTROLLED RELEASE,2007,123(3):184-194.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Ma, Baichao]'s Articles
 [Zhang, Shubiao]'s Articles
 [Jiang, Huiming]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Ma, Baichao]‘s Articles
 [Zhang, Shubiao]‘s Articles
 [Jiang, Huiming]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace