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题名: Biological fingerprinting analysis of traditional Chinese medicines with targeting ADME/Tox property for screening of bioactive compounds by chromatographic and MS methods
作者: Su, Xingye;  Kong, Liang;  Lei, Xiaoyuan;  Hu, Lianghai;  Ye, Mingliang;  Zou, Hanfa
关键词: biological fingerprinting analysis (BFA) ;  natural products ;  traditional Chinese medicine ;  screening ;  bioactive compounds ;  ADME/Tox ;  small molecule-biomacromolecule binding
刊名: MINI-REVIEWS IN MEDICINAL CHEMISTRY
发表日期: 2007
卷: 7, 期:1, 页:87-98
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Chemistry, Medicinal
研究领域[WOS]: Pharmacology & Pharmacy
英文摘要: Traditional Chinese medicines (TCMs) are attracting increased global attention because of their potential to provide novel therapeutic agents based on substantial historical records of efficacy in man. Many strategies have been designed for the screening and selection of bioactive compounds from these complex natural products mixtures. Biological fingerprinting analysis (BFA), based on small molecule-biomacromolecule interactions in complex systems, has been applied to screen the multiple bioactive compounds in natural products. Here we review the chromatographic and MS approaches used for BFA of natural products with targeting absorption, distribution, metabolism, elimination and toxicity (ADME/Tox) properties. Such chromatographic methods cover a wide range of applications including liposome, serum proteins, liver homogenate and DNA profiling. MS methods for the characterization of molecular interactions between natural products and target molecules by ESI and MALDI-TOF MS are also discussed.
关键词[WOS]: HUMAN SERUM-ALBUMIN ;  PERFORMANCE LIQUID-CHROMATOGRAPHY ;  IMMOBILIZED LIPOSOME CHROMATOGRAPHY ;  COMPREHENSIVE 2-DIMENSIONAL HPLC ;  MASS-SPECTROMETRY ;  NATURAL-PRODUCTS ;  DRUG DISCOVERY ;  STATIONARY-PHASE ;  ACTIVE COMPOUNDS ;  AFFINITY-CHROMATOGRAPHY
语种: 英语
WOS记录号: WOS:000243031200011
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/140740
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China

Recommended Citation:
Su, Xingye,Kong, Liang,Lei, Xiaoyuan,et al. Biological fingerprinting analysis of traditional Chinese medicines with targeting ADME/Tox property for screening of bioactive compounds by chromatographic and MS methods[J]. MINI-REVIEWS IN MEDICINAL CHEMISTRY,2007,7(1):87-98.
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