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Synthesis and activity of the photoaffinity-labeled functional probe based on prenyl side-chain
Li Ling-Dong; Tang Wei; Liu Wu-Jun; Zhao Zong-Bao
KeywordPrenyl Side-chain Functional Probe Photoaffinity Labeling Chemical Proteomics
Source PublicationCHINESE JOURNAL OF ORGANIC CHEMISTRY
2008-03-01
Volume28Issue:3Pages:489-493
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Organic
WOS Research AreaChemistry
WOS KeywordPROTEIN FARNESYLTRANSFERASE ; FARNESYL TRANSFERASE ; DIPHOSPHATE ANALOGS ; CHEMICAL STRATEGIES ; PRENYLTRANSFERASES ; INHIBITORS ; PROTEOMICS ; REAGENTS
AbstractA novel functional probe bearing both a benzophenone moiety and a biotin moiety was synthesized in 5 steps with an overall yield of 9%. Photoaffinity labeling and biotin blot experiment with the probe and the crude protein extracts from Saccharomyces cerevisiae AS 2.399 revealed that the synthetic probe was attached to a number of proteins, providing a basis for further chemical proteomics research.
Language英语
WOS IDWOS:000254422500023
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/140786
Collection中国科学院大连化学物理研究所
AffiliationChinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Li Ling-Dong,Tang Wei,Liu Wu-Jun,et al. Synthesis and activity of the photoaffinity-labeled functional probe based on prenyl side-chain[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2008,28(3):489-493.
APA Li Ling-Dong,Tang Wei,Liu Wu-Jun,&Zhao Zong-Bao.(2008).Synthesis and activity of the photoaffinity-labeled functional probe based on prenyl side-chain.CHINESE JOURNAL OF ORGANIC CHEMISTRY,28(3),489-493.
MLA Li Ling-Dong,et al."Synthesis and activity of the photoaffinity-labeled functional probe based on prenyl side-chain".CHINESE JOURNAL OF ORGANIC CHEMISTRY 28.3(2008):489-493.
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