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Synthesis and activity of the photoaffinity-labeled functional probe based on prenyl side-chain
Li Ling-Dong; Tang Wei; Liu Wu-Jun; Zhao Zong-Bao
关键词Prenyl Side-chain Functional Probe Photoaffinity Labeling Chemical Proteomics
刊名CHINESE JOURNAL OF ORGANIC CHEMISTRY
2008-03-01
28期:3页:489-493
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]PROTEIN FARNESYLTRANSFERASE ; FARNESYL TRANSFERASE ; DIPHOSPHATE ANALOGS ; CHEMICAL STRATEGIES ; PRENYLTRANSFERASES ; INHIBITORS ; PROTEOMICS ; REAGENTS
英文摘要A novel functional probe bearing both a benzophenone moiety and a biotin moiety was synthesized in 5 steps with an overall yield of 9%. Photoaffinity labeling and biotin blot experiment with the probe and the crude protein extracts from Saccharomyces cerevisiae AS 2.399 revealed that the synthetic probe was attached to a number of proteins, providing a basis for further chemical proteomics research.
语种英语
WOS记录号WOS:000254422500023
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/140786
专题中国科学院大连化学物理研究所
作者单位Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China
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Li Ling-Dong,Tang Wei,Liu Wu-Jun,et al. Synthesis and activity of the photoaffinity-labeled functional probe based on prenyl side-chain[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2008,28(3):489-493.
APA Li Ling-Dong,Tang Wei,Liu Wu-Jun,&Zhao Zong-Bao.(2008).Synthesis and activity of the photoaffinity-labeled functional probe based on prenyl side-chain.CHINESE JOURNAL OF ORGANIC CHEMISTRY,28(3),489-493.
MLA Li Ling-Dong,et al."Synthesis and activity of the photoaffinity-labeled functional probe based on prenyl side-chain".CHINESE JOURNAL OF ORGANIC CHEMISTRY 28.3(2008):489-493.
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