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题名: Synthesis and activity of the photoaffinity-labeled functional probe based on prenyl side-chain
作者: Li Ling-Dong1;  Tang Wei1;  Liu Wu-Jun1;  Zhao Zong-Bao1
关键词: prenyl side-chain ;  functional probe ;  photoaffinity labeling ;  chemical proteomics
刊名: CHINESE JOURNAL OF ORGANIC CHEMISTRY
发表日期: 2008-03-01
卷: 28, 期:3, 页:489-493
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
英文摘要: A novel functional probe bearing both a benzophenone moiety and a biotin moiety was synthesized in 5 steps with an overall yield of 9%. Photoaffinity labeling and biotin blot experiment with the probe and the crude protein extracts from Saccharomyces cerevisiae AS 2.399 revealed that the synthetic probe was attached to a number of proteins, providing a basis for further chemical proteomics research.
关键词[WOS]: PROTEIN FARNESYLTRANSFERASE ;  FARNESYL TRANSFERASE ;  DIPHOSPHATE ANALOGS ;  CHEMICAL STRATEGIES ;  PRENYLTRANSFERASES ;  INHIBITORS ;  PROTEOMICS ;  REAGENTS
语种: 英语
WOS记录号: WOS:000254422500023
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/140786
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China

Recommended Citation:
Li Ling-Dong,Tang Wei,Liu Wu-Jun,et al. Synthesis and activity of the photoaffinity-labeled functional probe based on prenyl side-chain[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2008,28(3):489-493.
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