DICP OpenIR
Chiral 1,2,3,4-tetrahydro-1-naphthylamine-derived phosphine-phosphoramidite ligand (THNAPhos): Application in highly enantioselective hydrogenations of functionalized C=C bonds
Qiu, Min; Hu, Xiang-Ping; Wang, Dao-Yong; Deng, Jun; Huang, Jia-Di; Yu, Sai-Bo; Duan, Zheng-Chao; Zheng, Zhuo
KeywordAsymmetric Catalysis Hydrogenation Olefins Phosphine-phosphoramidite Ligand
Source PublicationADVANCED SYNTHESIS & CATALYSIS
2008-06-01
DOI10.1002/adsc.200800152
Volume350Issue:9Pages:1413-1418
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Applied ; Chemistry, Organic
WOS Research AreaChemistry
WOS KeywordCATALYZED ASYMMETRIC HYDROGENATION ; PHOSPHONIC ACID-DERIVATIVES ; ALPHA-AMINO ; MICELLAR MEDIA ; HYDROXY ; COMPLEXES ; QUINAPHOS ; ESTERS
AbstractWe have recently reported a new chiral 1,2,3,4-tetrahydro-1-naphthylamine-derived phosphine-phosphoramidite ligand, (R-c,R-a)-THNAPhos, that is highly efficient in the rhodium-catalyzed asymmetric hydrogenation of a broad range of alpha-enol ester phosphonates. To further demonstrate the utility of THNAPhos in asymmetric hydrogenation, in this paper, we describe its new application in the asymmetric hydrogenation of alpha-dehydroamino acid esters, enamides, dimethyl itaconate and alpha-enamido phosphonates. The results disclosed that the Rh/(R-c,R-a)-THNAPhos complex is highly effective for the enantioselective hydrogenation of these kinds of functionalized C=C olefins, affording the corresponding hydrogenation product in excellent enantioselectivities (normally over 99% ee).
Language英语
WOS IDWOS:000256976100035
Citation statistics
Cited Times:31[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/140797
Collection中国科学院大连化学物理研究所
AffiliationChinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Qiu, Min,Hu, Xiang-Ping,Wang, Dao-Yong,et al. Chiral 1,2,3,4-tetrahydro-1-naphthylamine-derived phosphine-phosphoramidite ligand (THNAPhos): Application in highly enantioselective hydrogenations of functionalized C=C bonds[J]. ADVANCED SYNTHESIS & CATALYSIS,2008,350(9):1413-1418.
APA Qiu, Min.,Hu, Xiang-Ping.,Wang, Dao-Yong.,Deng, Jun.,Huang, Jia-Di.,...&Zheng, Zhuo.(2008).Chiral 1,2,3,4-tetrahydro-1-naphthylamine-derived phosphine-phosphoramidite ligand (THNAPhos): Application in highly enantioselective hydrogenations of functionalized C=C bonds.ADVANCED SYNTHESIS & CATALYSIS,350(9),1413-1418.
MLA Qiu, Min,et al."Chiral 1,2,3,4-tetrahydro-1-naphthylamine-derived phosphine-phosphoramidite ligand (THNAPhos): Application in highly enantioselective hydrogenations of functionalized C=C bonds".ADVANCED SYNTHESIS & CATALYSIS 350.9(2008):1413-1418.
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