DICP OpenIR
Organocatalytic highly enantioselective Michael addition of 2-hydroxy-1,4-naphthoquinones to nitroalkenes
Zhou, Wen-Ming; Liu, Han; Du, Da-Ming
Source PublicationORGANIC LETTERS
2008-07-03
DOI10.1021/ol800945e
Volume10Issue:13Pages:2817-2820
Indexed BySCI ; IC ; CCR
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Organic
WOS Research AreaChemistry
WOS KeywordFRIEDEL-CRAFTS ALKYLATION ; CONJUGATE ADDITION ; ASYMMETRIC ORGANOCATALYSIS ; ANTICANCER AGENTS ; 1,4-NAPHTHOQUINONE DERIVATIVES ; BIFUNCTIONAL ORGANOCATALYSTS ; CINCHONA ORGANOCATALYSTS ; CYTOTOXIC EVALUATION ; MULTIPLE-SCLEROSIS ; DIPHENYL PHOSPHITE
AbstractThe first organocatalytic enantioselective Michael addition of 2-hydroxy-1,4-naphthoquinones to nitroalkenes for the direct synthesis of chiral nitroalkylated naphthoquinone derivatives was investigated. Good yields and excellent enantioselectivities (up to > 99% ee) could be achieved. This organocatalytic asymmetric Michael addition provides an efficient route torward the synthesis of optically active functionalized naphthoquinones.
Language英语
WOS IDWOS:000257211400051
Citation statistics
Cited Times:68[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/140820
Collection中国科学院大连化学物理研究所
AffiliationPeking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Coll Chem & Mol Engn, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Wen-Ming,Liu, Han,Du, Da-Ming. Organocatalytic highly enantioselective Michael addition of 2-hydroxy-1,4-naphthoquinones to nitroalkenes[J]. ORGANIC LETTERS,2008,10(13):2817-2820.
APA Zhou, Wen-Ming,Liu, Han,&Du, Da-Ming.(2008).Organocatalytic highly enantioselective Michael addition of 2-hydroxy-1,4-naphthoquinones to nitroalkenes.ORGANIC LETTERS,10(13),2817-2820.
MLA Zhou, Wen-Ming,et al."Organocatalytic highly enantioselective Michael addition of 2-hydroxy-1,4-naphthoquinones to nitroalkenes".ORGANIC LETTERS 10.13(2008):2817-2820.
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