中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
题名: Serum metabolic profiling of abnormal savda by liquid chromatography/mass spectrometry
作者: Yin, Peiyuan2;  Mohemaiti, Patamu1;  Chen, Jing2;  Zhao, Xinjie2;  Lu, Xin2;  Yimiti, Adilijiang1;  Upur, Halmurat1;  Xu, Guowang2
关键词: metabonomics ;  metabolic profiling ;  abnormal savda ;  Uigur medicine
刊名: JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
发表日期: 2008-08-15
DOI: 10.1016/j.jchromb.2008.05.043
卷: 871, 期:2, 页:322-327
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: Abnormal savda is a special symptom in Uigur medicine. The understanding of its metabolic origins is of great importance for the subsequent treatment. Here, a metabonomic Study of this symptom was carried Out using LC-MS based human serum metabolic profiling. Orthogonal signal correction partial least-squares discriminant analysis (OSC-PLS-DA) was used for the classification and prediction of abnormal savda. Potential biomarkers from metabonomics were also identified for a metabolic understanding of abnormal savda. As a result, our OSC-PLS-DA model had a satisfactory ability for separation and prediction of abnormal savda. The potential biomarkers including bilirubin, bile acids, tryptophan, phenylalanine and lyso-phosphatidylcholines indicated that abnormal savda could be related to some abnormal metabolisms within the body, including energy metabolism, absorption of nutrition, metabolism of lecithin on cell membrane, etc. To the best of our knowledge, this is the first study of abnormal savda based on serum metabolic profiling. The LC/MS-based metabonomic platform Could be a powerful tool for the classification of symptoms and for the development of this traditional medicine into an evidence-based one. (C) 2008 Elsevier B.V. All rights reserved.
关键词[WOS]: MULTIVARIATE STATISTICAL-ANALYSIS ;  FLIGHT MASS-SPECTROMETRY ;  METABONOMICS ;  MS ;  BIOMARKERS ;  BIOFLUIDS ;  MODELS ;  RATS ;  AGE
语种: 英语
WOS记录号: WOS:000259130400021
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/140826
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Xinjiang Med Univ, Urumqi 830001, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China

Recommended Citation:
Yin, Peiyuan,Mohemaiti, Patamu,Chen, Jing,et al. Serum metabolic profiling of abnormal savda by liquid chromatography/mass spectrometry[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2008,871(2):322-327.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Yin, Peiyuan]'s Articles
 [Mohemaiti, Patamu]'s Articles
 [Chen, Jing]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Yin, Peiyuan]‘s Articles
 [Mohemaiti, Patamu]‘s Articles
 [Chen, Jing]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace