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Serum metabolic profiling of abnormal savda by liquid chromatography/mass spectrometry
Yin, Peiyuan2; Mohemaiti, Patamu1; Chen, Jing2; Zhao, Xinjie2; Lu, Xin2; Yimiti, Adilijiang1; Upur, Halmurat1; Xu, Guowang2
关键词Metabonomics Metabolic Profiling Abnormal Savda Uigur Medicine
刊名JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
2008-08-15
DOI10.1016/j.jchromb.2008.05.043
871期:2页:322-327
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]MULTIVARIATE STATISTICAL-ANALYSIS ; FLIGHT MASS-SPECTROMETRY ; METABONOMICS ; MS ; BIOMARKERS ; BIOFLUIDS ; MODELS ; RATS ; AGE
英文摘要Abnormal savda is a special symptom in Uigur medicine. The understanding of its metabolic origins is of great importance for the subsequent treatment. Here, a metabonomic Study of this symptom was carried Out using LC-MS based human serum metabolic profiling. Orthogonal signal correction partial least-squares discriminant analysis (OSC-PLS-DA) was used for the classification and prediction of abnormal savda. Potential biomarkers from metabonomics were also identified for a metabolic understanding of abnormal savda. As a result, our OSC-PLS-DA model had a satisfactory ability for separation and prediction of abnormal savda. The potential biomarkers including bilirubin, bile acids, tryptophan, phenylalanine and lyso-phosphatidylcholines indicated that abnormal savda could be related to some abnormal metabolisms within the body, including energy metabolism, absorption of nutrition, metabolism of lecithin on cell membrane, etc. To the best of our knowledge, this is the first study of abnormal savda based on serum metabolic profiling. The LC/MS-based metabonomic platform Could be a powerful tool for the classification of symptoms and for the development of this traditional medicine into an evidence-based one. (C) 2008 Elsevier B.V. All rights reserved.
语种英语
WOS记录号WOS:000259130400021
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文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/140826
专题中国科学院大连化学物理研究所
作者单位1.Xinjiang Med Univ, Urumqi 830001, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China
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Yin, Peiyuan,Mohemaiti, Patamu,Chen, Jing,et al. Serum metabolic profiling of abnormal savda by liquid chromatography/mass spectrometry[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2008,871(2):322-327.
APA Yin, Peiyuan.,Mohemaiti, Patamu.,Chen, Jing.,Zhao, Xinjie.,Lu, Xin.,...&Xu, Guowang.(2008).Serum metabolic profiling of abnormal savda by liquid chromatography/mass spectrometry.JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,871(2),322-327.
MLA Yin, Peiyuan,et al."Serum metabolic profiling of abnormal savda by liquid chromatography/mass spectrometry".JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 871.2(2008):322-327.
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