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LC-MS-based metabonomics analysis
Lu, Xin; Zhao, Xinjie; Bai, Changmin; Zhao, Chunxia; Lu, Guo; Xu, Guomang
KeywordHplc-ms Metabonomics Metabolic Profiling Metabolomics
Source PublicationJOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
2008-04-15
DOI10.1016/j.jchromb.2007.10.022
Volume866Issue:1-2Pages:64-76
Indexed BySCI
SubtypeReview
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectBiochemical Research Methods ; Chemistry, Analytical
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS KeywordTANDEM MASS-SPECTROMETRY ; PERFORMANCE LIQUID-CHROMATOGRAPHY ; MULTIVARIATE STATISTICAL-ANALYSIS ; CHIP-BASED INFUSION ; ATMOSPHERIC-PRESSURE PHOTOIONIZATION ; HEAVY-METAL TOXICITY ; RAT URINE ; DRUG METABOLITES ; ELECTROSPRAY-IONIZATION ; HPLC-TOF/MS
AbstractMetabonomics aims at the comprehensive and quantitative analysis of wide arrays of metabolites in biological samples. It has shown particular promise in the areas of toxicology and drug development, functional genomics, systems biology, and clinical diagnosis. Comprehensive metabonomics investigations are primarily a challenge for analytical chemistry. High-performance liquid chromatography-mass spectrometry (HPLC-MS) is an established technology in drug metabolite analysis and is now expanding into endogenous metabolite research. Its main advantages include wide dynamic range, reproducible quantitative analysis, and the ability to analyze biofluids with extreme molecular complexity. The aims of developing HPLC-MS for metabonomics range from understanding basic biochemistry to biomarker discovery and the structural characterization of physiologically important metabolites. In this review, the strategy and application of HPLC-MS-based metabonomics are reviewed. (C) 2007 Elsevier B.V. All rights reserved.
Language英语
WOS IDWOS:000255544100006
Citation statistics
Cited Times:111[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/140834
Collection中国科学院大连化学物理研究所
AffiliationChinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Lu, Xin,Zhao, Xinjie,Bai, Changmin,et al. LC-MS-based metabonomics analysis[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2008,866(1-2):64-76.
APA Lu, Xin,Zhao, Xinjie,Bai, Changmin,Zhao, Chunxia,Lu, Guo,&Xu, Guomang.(2008).LC-MS-based metabonomics analysis.JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,866(1-2),64-76.
MLA Lu, Xin,et al."LC-MS-based metabonomics analysis".JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 866.1-2(2008):64-76.
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