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题名: LC-MS-based metabonomics analysis
作者: Lu, Xin1;  Zhao, Xinjie1;  Bai, Changmin1;  Zhao, Chunxia1;  Lu, Guo1;  Xu, Guomang1
关键词: HPLC-MS ;  metabonomics ;  metabolic profiling ;  metabolomics
刊名: JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
发表日期: 2008-04-15
DOI: 10.1016/j.jchromb.2007.10.022
卷: 866, 期:1-2, 页:64-76
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: Metabonomics aims at the comprehensive and quantitative analysis of wide arrays of metabolites in biological samples. It has shown particular promise in the areas of toxicology and drug development, functional genomics, systems biology, and clinical diagnosis. Comprehensive metabonomics investigations are primarily a challenge for analytical chemistry. High-performance liquid chromatography-mass spectrometry (HPLC-MS) is an established technology in drug metabolite analysis and is now expanding into endogenous metabolite research. Its main advantages include wide dynamic range, reproducible quantitative analysis, and the ability to analyze biofluids with extreme molecular complexity. The aims of developing HPLC-MS for metabonomics range from understanding basic biochemistry to biomarker discovery and the structural characterization of physiologically important metabolites. In this review, the strategy and application of HPLC-MS-based metabonomics are reviewed. (C) 2007 Elsevier B.V. All rights reserved.
关键词[WOS]: TANDEM MASS-SPECTROMETRY ;  PERFORMANCE LIQUID-CHROMATOGRAPHY ;  MULTIVARIATE STATISTICAL-ANALYSIS ;  CHIP-BASED INFUSION ;  ATMOSPHERIC-PRESSURE PHOTOIONIZATION ;  HEAVY-METAL TOXICITY ;  RAT URINE ;  DRUG METABOLITES ;  ELECTROSPRAY-IONIZATION ;  HPLC-TOF/MS
语种: 英语
WOS记录号: WOS:000255544100006
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/140834
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China

Recommended Citation:
Lu, Xin,Zhao, Xinjie,Bai, Changmin,et al. LC-MS-based metabonomics analysis[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2008,866(1-2):64-76.
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