DICP OpenIR
LC-MS-based metabonomics analysis
Lu, Xin; Zhao, Xinjie; Bai, Changmin; Zhao, Chunxia; Lu, Guo; Xu, Guomang
关键词Hplc-ms Metabonomics Metabolic Profiling Metabolomics
刊名JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
2008-04-15
DOI10.1016/j.jchromb.2007.10.022
866期:1-2页:64-76
收录类别SCI
文章类型Review
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]TANDEM MASS-SPECTROMETRY ; PERFORMANCE LIQUID-CHROMATOGRAPHY ; MULTIVARIATE STATISTICAL-ANALYSIS ; CHIP-BASED INFUSION ; ATMOSPHERIC-PRESSURE PHOTOIONIZATION ; HEAVY-METAL TOXICITY ; RAT URINE ; DRUG METABOLITES ; ELECTROSPRAY-IONIZATION ; HPLC-TOF/MS
英文摘要Metabonomics aims at the comprehensive and quantitative analysis of wide arrays of metabolites in biological samples. It has shown particular promise in the areas of toxicology and drug development, functional genomics, systems biology, and clinical diagnosis. Comprehensive metabonomics investigations are primarily a challenge for analytical chemistry. High-performance liquid chromatography-mass spectrometry (HPLC-MS) is an established technology in drug metabolite analysis and is now expanding into endogenous metabolite research. Its main advantages include wide dynamic range, reproducible quantitative analysis, and the ability to analyze biofluids with extreme molecular complexity. The aims of developing HPLC-MS for metabonomics range from understanding basic biochemistry to biomarker discovery and the structural characterization of physiologically important metabolites. In this review, the strategy and application of HPLC-MS-based metabonomics are reviewed. (C) 2007 Elsevier B.V. All rights reserved.
语种英语
WOS记录号WOS:000255544100006
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/140834
专题中国科学院大连化学物理研究所
作者单位Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China
推荐引用方式
GB/T 7714
Lu, Xin,Zhao, Xinjie,Bai, Changmin,et al. LC-MS-based metabonomics analysis[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2008,866(1-2):64-76.
APA Lu, Xin,Zhao, Xinjie,Bai, Changmin,Zhao, Chunxia,Lu, Guo,&Xu, Guomang.(2008).LC-MS-based metabonomics analysis.JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,866(1-2),64-76.
MLA Lu, Xin,et al."LC-MS-based metabonomics analysis".JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 866.1-2(2008):64-76.
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