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Two-dimensional LC-MS analysis of components in Swertia franchetiana Smith
Liu, Yanming; Xu, Qing; Xue, Xingya; Zhang, Feifang; Liang, Xinmiao
关键词Mass Spectrometry On-column Focusing Swertia Franchetiana Smith Traditional Chinese Medicine Two-dimensional Liquid Chromatography
刊名JOURNAL OF SEPARATION SCIENCE
2008-04-01
DOI10.1002/jssc.200700393
31期:6-7页:935-944
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Analytical
研究领域[WOS]Chemistry
关键词[WOS]PERFORMANCE LIQUID-CHROMATOGRAPHY ; TRADITIONAL CHINESE MEDICINES ; MASS-SPECTROMETRY ; REVERSED-PHASE ; GAS-CHROMATOGRAPHY ; AUTOMATED INSTRUMENTATION ; COLUMN ; HPLC ; SEPARATION ; ONLINE
英文摘要An off-line 2-D-LC approach was developed for the separation and identification of components in extracts of Swertia franchetiana Smith, which is a traditional Chinese medicine. An octadecylsilica column was used for further separation of fractions from a cyano column with UV and MS detection. In this method, a longer column was used in the second dimension to improve the separation ability, and "on-column focusing" was adopted to reduce sample loss and pollution on concentrating the fractions from the first dimension. More than 118 and 575 components were detected in the chloroform and n-butanol extracts by this method, respectively. In contrast, only 20 and 95 peaks were detected by the one-dimensional method. Most of the additionally detected compounds were of low-abundance components. Many compounds can be preliminarily identified according to their UV and mass spectra in the two-dimensional method. The obtained results not only demonstrated the powerful resolution of 2-D-LC, but also led to in-depth comprehension of the UV and mass spectra of complex samples.
语种英语
WOS记录号WOS:000255613800005
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被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/140839
专题中国科学院大连化学物理研究所
作者单位Chinese Acad Sci, Dalian Inst Chem Phys, Grad Sch, Dalian 116023, Peoples R China
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GB/T 7714
Liu, Yanming,Xu, Qing,Xue, Xingya,et al. Two-dimensional LC-MS analysis of components in Swertia franchetiana Smith[J]. JOURNAL OF SEPARATION SCIENCE,2008,31(6-7):935-944.
APA Liu, Yanming,Xu, Qing,Xue, Xingya,Zhang, Feifang,&Liang, Xinmiao.(2008).Two-dimensional LC-MS analysis of components in Swertia franchetiana Smith.JOURNAL OF SEPARATION SCIENCE,31(6-7),935-944.
MLA Liu, Yanming,et al."Two-dimensional LC-MS analysis of components in Swertia franchetiana Smith".JOURNAL OF SEPARATION SCIENCE 31.6-7(2008):935-944.
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