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题名: Mass spectrometry-based neurochemical analysis: perspectives for primate research
作者: Zhang, Xiaozhe1;  Rauch, Alexander1;  Xiao, Hongbin2;  Rainer, Gregor1, 3;  Logothetis, Nikos K.1
关键词: biomarker ;  extracellular brain fluid ;  hydrophilic interaction liquid chromatography ;  mass spectrometry ;  neurochemical analysis ;  neuropeptide ;  neurotransmitter ;  nonhuman primate
刊名: EXPERT REVIEW OF PROTEOMICS
发表日期: 2008-10-01
DOI: 10.1586/14789450.5.5.641
卷: 5, 期:5, 页:641-652
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemical Research Methods
研究领域[WOS]: Biochemistry & Molecular Biology
英文摘要: The analysis of neurochemicals from the brain represents a challenge for current analytical techniques due to a variety of factors, such as compositional complexity, limited amounts of sample and endogenous inferences. Advances in mass spectrometry (MS) provide great opportunities for the sensitive measurement of neurochemicals, offering benefits including simple sample preparation, broad capability for analysis of diverse compounds and rich structural information of analytes. Until recently, however, limited numbers of studies have reported on the analysis of small molecular neurochemicals, such as classical neurotransmitters, in part due to the difficulties in separation of polar molecules by using current chromatography techniques with MS-compatible conditions. By contrast, MS has become an indispensable tool for neuropeptide analysis, offering tremendous potential in the discovery of novel signaling peptides and biomarkers. This review covers recent advances in MS-based neurochemical analysis, including a comparison with related detection techniques, chromatographic separation and neuropeptide discovery. Issues relating to in vivo sample collection and sample preparation are discussed. To provide a wider view of the capability of MS in basic neuroscience and clinical research, we discuss MS-based neurochemical analysis conducted in different animal models and humans. We specifically highlight perspectives for the use of MS for brain functional studies and drug discovery in nonhuman primates.
关键词[WOS]: HYDROPHILIC-INTERACTION CHROMATOGRAPHY ;  LASER-INDUCED FLUORESCENCE ;  HUMAN CEREBROSPINAL-FLUID ;  IN-VIVO MICRODIALYSIS ;  ATMOSPHERIC-PRESSURE PHOTOIONIZATION ;  CAPILLARY LIQUID-CHROMATOGRAPHY ;  ELECTROSPRAY-IONIZATION ;  ALZHEIMERS-DISEASE ;  POLAR COMPOUNDS ;  RAT-BRAIN
语种: 英语
WOS记录号: WOS:000260701000006
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/140841
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Max Planck Inst Biol Cybernet, Dept Physiol Cognit Proc, D-72076 Tubingen, Germany
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dept Biotechnol, Dalian 116023, Peoples R China
3.Dept Med Physiol, CH-1700 Fribourg, Switzerland

Recommended Citation:
Zhang, Xiaozhe,Rauch, Alexander,Xiao, Hongbin,et al. Mass spectrometry-based neurochemical analysis: perspectives for primate research[J]. EXPERT REVIEW OF PROTEOMICS,2008,5(5):641-652.
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