DICP OpenIR
Mass spectrometry-based neurochemical analysis: perspectives for primate research
Zhang, Xiaozhe1; Rauch, Alexander1; Xiao, Hongbin2; Rainer, Gregor1,3; Logothetis, Nikos K.1
KeywordBiomarker Extracellular Brain Fluid Hydrophilic Interaction Liquid Chromatography Mass Spectrometry Neurochemical Analysis Neuropeptide Neurotransmitter Nonhuman Primate
Source PublicationEXPERT REVIEW OF PROTEOMICS
2008-10-01
DOI10.1586/14789450.5.5.641
Volume5Issue:5Pages:641-652
Indexed BySCI
SubtypeReview
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectBiochemical Research Methods
WOS Research AreaBiochemistry & Molecular Biology
WOS KeywordHYDROPHILIC-INTERACTION CHROMATOGRAPHY ; LASER-INDUCED FLUORESCENCE ; HUMAN CEREBROSPINAL-FLUID ; IN-VIVO MICRODIALYSIS ; ATMOSPHERIC-PRESSURE PHOTOIONIZATION ; CAPILLARY LIQUID-CHROMATOGRAPHY ; ELECTROSPRAY-IONIZATION ; ALZHEIMERS-DISEASE ; POLAR COMPOUNDS ; RAT-BRAIN
AbstractThe analysis of neurochemicals from the brain represents a challenge for current analytical techniques due to a variety of factors, such as compositional complexity, limited amounts of sample and endogenous inferences. Advances in mass spectrometry (MS) provide great opportunities for the sensitive measurement of neurochemicals, offering benefits including simple sample preparation, broad capability for analysis of diverse compounds and rich structural information of analytes. Until recently, however, limited numbers of studies have reported on the analysis of small molecular neurochemicals, such as classical neurotransmitters, in part due to the difficulties in separation of polar molecules by using current chromatography techniques with MS-compatible conditions. By contrast, MS has become an indispensable tool for neuropeptide analysis, offering tremendous potential in the discovery of novel signaling peptides and biomarkers. This review covers recent advances in MS-based neurochemical analysis, including a comparison with related detection techniques, chromatographic separation and neuropeptide discovery. Issues relating to in vivo sample collection and sample preparation are discussed. To provide a wider view of the capability of MS in basic neuroscience and clinical research, we discuss MS-based neurochemical analysis conducted in different animal models and humans. We specifically highlight perspectives for the use of MS for brain functional studies and drug discovery in nonhuman primates.
Language英语
WOS IDWOS:000260701000006
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/140841
Collection中国科学院大连化学物理研究所
Affiliation1.Max Planck Inst Biol Cybernet, Dept Physiol Cognit Proc, D-72076 Tubingen, Germany
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dept Biotechnol, Dalian 116023, Peoples R China
3.Dept Med Physiol, CH-1700 Fribourg, Switzerland
Recommended Citation
GB/T 7714
Zhang, Xiaozhe,Rauch, Alexander,Xiao, Hongbin,et al. Mass spectrometry-based neurochemical analysis: perspectives for primate research[J]. EXPERT REVIEW OF PROTEOMICS,2008,5(5):641-652.
APA Zhang, Xiaozhe,Rauch, Alexander,Xiao, Hongbin,Rainer, Gregor,&Logothetis, Nikos K..(2008).Mass spectrometry-based neurochemical analysis: perspectives for primate research.EXPERT REVIEW OF PROTEOMICS,5(5),641-652.
MLA Zhang, Xiaozhe,et al."Mass spectrometry-based neurochemical analysis: perspectives for primate research".EXPERT REVIEW OF PROTEOMICS 5.5(2008):641-652.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhang, Xiaozhe]'s Articles
[Rauch, Alexander]'s Articles
[Xiao, Hongbin]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhang, Xiaozhe]'s Articles
[Rauch, Alexander]'s Articles
[Xiao, Hongbin]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhang, Xiaozhe]'s Articles
[Rauch, Alexander]'s Articles
[Xiao, Hongbin]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.