DICP OpenIR
Mass spectrometry-based neurochemical analysis: perspectives for primate research
Zhang, Xiaozhe1; Rauch, Alexander1; Xiao, Hongbin2; Rainer, Gregor1,3; Logothetis, Nikos K.1
关键词Biomarker Extracellular Brain Fluid Hydrophilic Interaction Liquid Chromatography Mass Spectrometry Neurochemical Analysis Neuropeptide Neurotransmitter Nonhuman Primate
刊名EXPERT REVIEW OF PROTEOMICS
2008-10-01
DOI10.1586/14789450.5.5.641
5期:5页:641-652
收录类别SCI
文章类型Review
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Biochemical Research Methods
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]HYDROPHILIC-INTERACTION CHROMATOGRAPHY ; LASER-INDUCED FLUORESCENCE ; HUMAN CEREBROSPINAL-FLUID ; IN-VIVO MICRODIALYSIS ; ATMOSPHERIC-PRESSURE PHOTOIONIZATION ; CAPILLARY LIQUID-CHROMATOGRAPHY ; ELECTROSPRAY-IONIZATION ; ALZHEIMERS-DISEASE ; POLAR COMPOUNDS ; RAT-BRAIN
英文摘要The analysis of neurochemicals from the brain represents a challenge for current analytical techniques due to a variety of factors, such as compositional complexity, limited amounts of sample and endogenous inferences. Advances in mass spectrometry (MS) provide great opportunities for the sensitive measurement of neurochemicals, offering benefits including simple sample preparation, broad capability for analysis of diverse compounds and rich structural information of analytes. Until recently, however, limited numbers of studies have reported on the analysis of small molecular neurochemicals, such as classical neurotransmitters, in part due to the difficulties in separation of polar molecules by using current chromatography techniques with MS-compatible conditions. By contrast, MS has become an indispensable tool for neuropeptide analysis, offering tremendous potential in the discovery of novel signaling peptides and biomarkers. This review covers recent advances in MS-based neurochemical analysis, including a comparison with related detection techniques, chromatographic separation and neuropeptide discovery. Issues relating to in vivo sample collection and sample preparation are discussed. To provide a wider view of the capability of MS in basic neuroscience and clinical research, we discuss MS-based neurochemical analysis conducted in different animal models and humans. We specifically highlight perspectives for the use of MS for brain functional studies and drug discovery in nonhuman primates.
语种英语
WOS记录号WOS:000260701000006
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/140841
专题中国科学院大连化学物理研究所
作者单位1.Max Planck Inst Biol Cybernet, Dept Physiol Cognit Proc, D-72076 Tubingen, Germany
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dept Biotechnol, Dalian 116023, Peoples R China
3.Dept Med Physiol, CH-1700 Fribourg, Switzerland
推荐引用方式
GB/T 7714
Zhang, Xiaozhe,Rauch, Alexander,Xiao, Hongbin,et al. Mass spectrometry-based neurochemical analysis: perspectives for primate research[J]. EXPERT REVIEW OF PROTEOMICS,2008,5(5):641-652.
APA Zhang, Xiaozhe,Rauch, Alexander,Xiao, Hongbin,Rainer, Gregor,&Logothetis, Nikos K..(2008).Mass spectrometry-based neurochemical analysis: perspectives for primate research.EXPERT REVIEW OF PROTEOMICS,5(5),641-652.
MLA Zhang, Xiaozhe,et al."Mass spectrometry-based neurochemical analysis: perspectives for primate research".EXPERT REVIEW OF PROTEOMICS 5.5(2008):641-652.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, Xiaozhe]的文章
[Rauch, Alexander]的文章
[Xiao, Hongbin]的文章
百度学术
百度学术中相似的文章
[Zhang, Xiaozhe]的文章
[Rauch, Alexander]的文章
[Xiao, Hongbin]的文章
必应学术
必应学术中相似的文章
[Zhang, Xiaozhe]的文章
[Rauch, Alexander]的文章
[Xiao, Hongbin]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。