DICP OpenIR
Enantioselective synthesis of beta-aryl-gamma-amino acid derivatives via Cu-catalyzed asymmetric 1,4-reductions of gamma-phthalimido-substituted alpha,beta-unsaturated carboxylic acid esters
Deng, Jun1,2; Hu, Xiang-Ping1; Huang, Jia-Di1,2; Yu, Sai-Bo1,2; Wang, Dao-Yong1,2; Duan, Zheng-Chao1,2; Zheng, Zhuo1,2
Source PublicationJOURNAL OF ORGANIC CHEMISTRY
2008-08-01
DOI10.1021/jo800794p
Volume73Issue:15Pages:6022-6024
Indexed BySCI ; CCR
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Organic
WOS Research AreaChemistry
WOS KeywordDYNAMIC KINETIC-RESOLUTION ; CONJUGATE REDUCTION ; STEREOSELECTIVE-SYNTHESIS ; ANTICONVULSANT AGENTS ; GABA ANALOGS ; BACLOFEN ; HYDROSILYLATION ; (R)-(-)-BACLOFEN ; (-)-(R)-BACLOFEN ; HYDROGENATION
AbstractA series of chiral beta-aryl-substituted) gamma-amino butyric acid derivatives were synthesized in good enantioselectivities via the Cu-catalyzed asymmetric conjugate reduction of gamma-phthalimido-alpha,beta-unsaturated carboxylic acid esters using Cu(OAC)(2)center dot H(2)O as a catalyst precursor, (S)-BINAP as a ligand, PMHS as a hydride source, and t-BuOH as an additive. The methodology has been applied successfully to the enantioselective synthesis of a chiral pharmaceutical, (R)-baclofen.
Language英语
WOS IDWOS:000257953600044
Citation statistics
Cited Times:28[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/140893
Collection中国科学院大连化学物理研究所
Affiliation1.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Deng, Jun,Hu, Xiang-Ping,Huang, Jia-Di,et al. Enantioselective synthesis of beta-aryl-gamma-amino acid derivatives via Cu-catalyzed asymmetric 1,4-reductions of gamma-phthalimido-substituted alpha,beta-unsaturated carboxylic acid esters[J]. JOURNAL OF ORGANIC CHEMISTRY,2008,73(15):6022-6024.
APA Deng, Jun.,Hu, Xiang-Ping.,Huang, Jia-Di.,Yu, Sai-Bo.,Wang, Dao-Yong.,...&Zheng, Zhuo.(2008).Enantioselective synthesis of beta-aryl-gamma-amino acid derivatives via Cu-catalyzed asymmetric 1,4-reductions of gamma-phthalimido-substituted alpha,beta-unsaturated carboxylic acid esters.JOURNAL OF ORGANIC CHEMISTRY,73(15),6022-6024.
MLA Deng, Jun,et al."Enantioselective synthesis of beta-aryl-gamma-amino acid derivatives via Cu-catalyzed asymmetric 1,4-reductions of gamma-phthalimido-substituted alpha,beta-unsaturated carboxylic acid esters".JOURNAL OF ORGANIC CHEMISTRY 73.15(2008):6022-6024.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Deng, Jun]'s Articles
[Hu, Xiang-Ping]'s Articles
[Huang, Jia-Di]'s Articles
Baidu academic
Similar articles in Baidu academic
[Deng, Jun]'s Articles
[Hu, Xiang-Ping]'s Articles
[Huang, Jia-Di]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Deng, Jun]'s Articles
[Hu, Xiang-Ping]'s Articles
[Huang, Jia-Di]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.