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Enantioselective synthesis of beta-aryl-gamma-amino acid derivatives via Cu-catalyzed asymmetric 1,4-reductions of gamma-phthalimido-substituted alpha,beta-unsaturated carboxylic acid esters
Deng, Jun1,2; Hu, Xiang-Ping1; Huang, Jia-Di1,2; Yu, Sai-Bo1,2; Wang, Dao-Yong1,2; Duan, Zheng-Chao1,2; Zheng, Zhuo1,2
刊名JOURNAL OF ORGANIC CHEMISTRY
2008-08-01
DOI10.1021/jo800794p
73期:15页:6022-6024
收录类别SCI ; CCR
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]DYNAMIC KINETIC-RESOLUTION ; CONJUGATE REDUCTION ; STEREOSELECTIVE-SYNTHESIS ; ANTICONVULSANT AGENTS ; GABA ANALOGS ; BACLOFEN ; HYDROSILYLATION ; (R)-(-)-BACLOFEN ; (-)-(R)-BACLOFEN ; HYDROGENATION
英文摘要A series of chiral beta-aryl-substituted) gamma-amino butyric acid derivatives were synthesized in good enantioselectivities via the Cu-catalyzed asymmetric conjugate reduction of gamma-phthalimido-alpha,beta-unsaturated carboxylic acid esters using Cu(OAC)(2)center dot H(2)O as a catalyst precursor, (S)-BINAP as a ligand, PMHS as a hydride source, and t-BuOH as an additive. The methodology has been applied successfully to the enantioselective synthesis of a chiral pharmaceutical, (R)-baclofen.
语种英语
WOS记录号WOS:000257953600044
引用统计
被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/140893
专题中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
推荐引用方式
GB/T 7714
Deng, Jun,Hu, Xiang-Ping,Huang, Jia-Di,et al. Enantioselective synthesis of beta-aryl-gamma-amino acid derivatives via Cu-catalyzed asymmetric 1,4-reductions of gamma-phthalimido-substituted alpha,beta-unsaturated carboxylic acid esters[J]. JOURNAL OF ORGANIC CHEMISTRY,2008,73(15):6022-6024.
APA Deng, Jun.,Hu, Xiang-Ping.,Huang, Jia-Di.,Yu, Sai-Bo.,Wang, Dao-Yong.,...&Zheng, Zhuo.(2008).Enantioselective synthesis of beta-aryl-gamma-amino acid derivatives via Cu-catalyzed asymmetric 1,4-reductions of gamma-phthalimido-substituted alpha,beta-unsaturated carboxylic acid esters.JOURNAL OF ORGANIC CHEMISTRY,73(15),6022-6024.
MLA Deng, Jun,et al."Enantioselective synthesis of beta-aryl-gamma-amino acid derivatives via Cu-catalyzed asymmetric 1,4-reductions of gamma-phthalimido-substituted alpha,beta-unsaturated carboxylic acid esters".JOURNAL OF ORGANIC CHEMISTRY 73.15(2008):6022-6024.
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