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An integrated microfluidic chip for drug-metabolism
Zhang Guo-Hao; Ma Bo; Qin Jian-Hua; Lin Bing-Cheng
KeywordMicrofluidic Chip Drug-metabolism Microsome Sol-gel
Source PublicationCHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
2008-07-10
Volume29Issue:7Pages:1356-1358
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Multidisciplinary
WOS Research AreaChemistry
WOS KeywordMICROSOMES
AbstractIn this paper, we report an integrated microfluidic chip for drug-metabolism. The chip contains three layers: the top PDMS cover, the middle quartz slide with microchannels and microwells, the bottom PDMS layer for cell culture. Microsomes isolated from human liver were encapsulated in microwells by sol-gel method. Using this design, the determination of the metabolites and drug cytotoxicity assessment can be carried out within a single microfluidic device, providing an alternative technique for the high-throughput parallel drug screening and drug interactions in the metabolic pathways.
Language英语
WOS IDWOS:000258092900015
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/140903
Collection中国科学院大连化学物理研究所
AffiliationChinese Acad Sci, Dalian Inst Chem & Phys, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Zhang Guo-Hao,Ma Bo,Qin Jian-Hua,et al. An integrated microfluidic chip for drug-metabolism[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2008,29(7):1356-1358.
APA Zhang Guo-Hao,Ma Bo,Qin Jian-Hua,&Lin Bing-Cheng.(2008).An integrated microfluidic chip for drug-metabolism.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,29(7),1356-1358.
MLA Zhang Guo-Hao,et al."An integrated microfluidic chip for drug-metabolism".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 29.7(2008):1356-1358.
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