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An integrated microfluidic chip for drug-metabolism
Zhang Guo-Hao; Ma Bo; Qin Jian-Hua; Lin Bing-Cheng
关键词Microfluidic Chip Drug-metabolism Microsome Sol-gel
刊名CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
2008-07-10
29期:7页:1356-1358
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]MICROSOMES
英文摘要In this paper, we report an integrated microfluidic chip for drug-metabolism. The chip contains three layers: the top PDMS cover, the middle quartz slide with microchannels and microwells, the bottom PDMS layer for cell culture. Microsomes isolated from human liver were encapsulated in microwells by sol-gel method. Using this design, the determination of the metabolites and drug cytotoxicity assessment can be carried out within a single microfluidic device, providing an alternative technique for the high-throughput parallel drug screening and drug interactions in the metabolic pathways.
语种英语
WOS记录号WOS:000258092900015
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/140903
专题中国科学院大连化学物理研究所
作者单位Chinese Acad Sci, Dalian Inst Chem & Phys, Dalian 116023, Peoples R China
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GB/T 7714
Zhang Guo-Hao,Ma Bo,Qin Jian-Hua,et al. An integrated microfluidic chip for drug-metabolism[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2008,29(7):1356-1358.
APA Zhang Guo-Hao,Ma Bo,Qin Jian-Hua,&Lin Bing-Cheng.(2008).An integrated microfluidic chip for drug-metabolism.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,29(7),1356-1358.
MLA Zhang Guo-Hao,et al."An integrated microfluidic chip for drug-metabolism".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 29.7(2008):1356-1358.
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