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A multichannel electrophoresis microchip platform for rapid chiral selector screening
Gao, Yan; Luo, Yong; Qin, Jianhua; Lin, Bingcheng
关键词Chiral Selector Cycloclextrin High Throughput Microchip Electrophoresis Screening
刊名ELECTROPHORESIS
2008-05-01
DOI10.1002/elps.200700384
29期:9页:1918-1923
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]NUCLEAR-MAGNETIC-RESONANCE ; CAPILLARY-ELECTROPHORESIS ; ENANTIOMERIC SEPARATION ; ON-CHIP ; ENANTIOSELECTIVE CATALYSIS ; COMBINATORIAL LIBRARY ; LIQUID-CHROMATOGRAPHY ; MICROFLUIDIC CHIP ; CYCLODEXTRINS ; STRATEGY
英文摘要This study presents a four-channel electrophoresis chip platform, featuring double-cross hydrostatic sample injection, for rapid chiral selector screening. This platform needs only five electrodes to drive microchip electrophoresis in four separate channels for screening four chiral selectors at a time. To demonstrate the performance of this screening platform, eight neutral CDs and their derivatives as chiral selectors were screened towards two FITC-labeled chiral compounds. The screening could be accomplished in less than 2 min. Dimethyl-beta-CD and hydroxypropyl-alpha-CD was demonstrated to be the appropriate selectors for FITC-norfenefrine and FITC-baclofen, respectively. The established platform is easy to operate and suitable for rapid screening process, which is expected to be a potential platform for high-throughput screening of chiral selectors.
语种英语
WOS记录号WOS:000256510000019
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/140910
专题中国科学院大连化学物理研究所
作者单位Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
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GB/T 7714
Gao, Yan,Luo, Yong,Qin, Jianhua,et al. A multichannel electrophoresis microchip platform for rapid chiral selector screening[J]. ELECTROPHORESIS,2008,29(9):1918-1923.
APA Gao, Yan,Luo, Yong,Qin, Jianhua,&Lin, Bingcheng.(2008).A multichannel electrophoresis microchip platform for rapid chiral selector screening.ELECTROPHORESIS,29(9),1918-1923.
MLA Gao, Yan,et al."A multichannel electrophoresis microchip platform for rapid chiral selector screening".ELECTROPHORESIS 29.9(2008):1918-1923.
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