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题名: A multichannel electrophoresis microchip platform for rapid chiral selector screening
作者: Gao, Yan1;  Luo, Yong1;  Qin, Jianhua1;  Lin, Bingcheng1
关键词: chiral selector ;  cycloclextrin ;  high throughput ;  microchip electrophoresis ;  screening
刊名: ELECTROPHORESIS
发表日期: 2008-05-01
DOI: 10.1002/elps.200700384
卷: 29, 期:9, 页:1918-1923
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: This study presents a four-channel electrophoresis chip platform, featuring double-cross hydrostatic sample injection, for rapid chiral selector screening. This platform needs only five electrodes to drive microchip electrophoresis in four separate channels for screening four chiral selectors at a time. To demonstrate the performance of this screening platform, eight neutral CDs and their derivatives as chiral selectors were screened towards two FITC-labeled chiral compounds. The screening could be accomplished in less than 2 min. Dimethyl-beta-CD and hydroxypropyl-alpha-CD was demonstrated to be the appropriate selectors for FITC-norfenefrine and FITC-baclofen, respectively. The established platform is easy to operate and suitable for rapid screening process, which is expected to be a potential platform for high-throughput screening of chiral selectors.
关键词[WOS]: NUCLEAR-MAGNETIC-RESONANCE ;  CAPILLARY-ELECTROPHORESIS ;  ENANTIOMERIC SEPARATION ;  ON-CHIP ;  ENANTIOSELECTIVE CATALYSIS ;  COMBINATORIAL LIBRARY ;  LIQUID-CHROMATOGRAPHY ;  MICROFLUIDIC CHIP ;  CYCLODEXTRINS ;  STRATEGY
语种: 英语
WOS记录号: WOS:000256510000019
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/140910
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Recommended Citation:
Gao, Yan,Luo, Yong,Qin, Jianhua,et al. A multichannel electrophoresis microchip platform for rapid chiral selector screening[J]. ELECTROPHORESIS,2008,29(9):1918-1923.
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