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题名: A mesoporous silica nanoparticles immobilized open-tubular capillary column with a coating of cellulose tris(3,5-dimethylphenyl-carbamate) for enantioseparation in CEC
作者: Dong, Xiaoli1, 2;  Wu, Ren'an1;  Dong, Jing1;  Wu, Minghuo1;  Zhu, Yan2;  Zou, Hanfa1
关键词: Capillary electrochromatography ;  Cellulose tris(3,5-dimethylphenyl-carbamate) ;  Enantioseparation ;  MCM-41 ;  Open-tubular capillary column
刊名: ELECTROPHORESIS
发表日期: 2008-09-01
DOI: 10.1002/elps.200800025
卷: 29, 期:18, 页:3933-3940
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: An approach of immobilizing mobile crystalline material (MCM)-41 mesoporous silica nanoparticles on the inner wall of an open-tubular (OT) capillary as the support for coating chiral selector of cellulose tris(3,5-dimethylphenyl-carbamate) (CDMPC) was carried out. By taking advantage of the improved phase ratio of OT capillary with the immobilization of MCM-41 mesoporous material, the cellulose derivative of CDMPC as the chiral selector was simply coated on the MCM-41 nanoparticle layer via the hydrogen-bonding interaction, and the enantioseparation was successively carried out. Eight pairs of acidic, neutral and basic enantiomers were resolved in capillary electrochromatography or capillary liquid chromatography mode. The concentration of CDMPC for coating was systematically investigated to obtain the optimized chromatographic properties on enantioseparation by controlling the supposed film thickness of CDMPC on MCM-41 nanoparticle layer. Comparing with a bare fused silica capillary column coated with CDMPC under the same coating procedure as MCM-41-modified capillary did, the MCM-41-modified capillary column offered much higher enantioselectivity. This result indicated the significance of using the mesoporous nanoparticles as the electrochromatographic support to enhance the phase ratio of OT capillary column in capillary electrochromatography and capillary liquid chromatography. For investigating the effect of experimental conditions on the enantioseparation with this prepared OT capillary column, the content of organic modifier acetonitrile in the mobile phase was thus extensively evaluated to achieve a better chiral separation.
关键词[WOS]: TITANIUM-DIOXIDE NANOPARTICLES ;  EXCHANGE STATIONARY PHASES ;  ELECTROCHROMATOGRAPHIC SEPARATION ;  ENANTIOMER SEPARATION ;  LIQUID-CHROMATOGRAPHY ;  ION CHROMATOGRAPHY ;  MOLECULAR-SIEVES ;  IN-LINE ;  ELECTROPHORESIS ;  ADSORPTION
语种: 英语
WOS记录号: WOS:000260242100027
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/140911
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian, Peoples R China
2.Zhejiang Univ, Dept Chem, Hangzhou 310003, Zhejiang, Peoples R China

Recommended Citation:
Dong, Xiaoli,Wu, Ren'an,Dong, Jing,et al. A mesoporous silica nanoparticles immobilized open-tubular capillary column with a coating of cellulose tris(3,5-dimethylphenyl-carbamate) for enantioseparation in CEC[J]. ELECTROPHORESIS,2008,29(18):3933-3940.
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