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题名: Investigation of formation, recognition, stabilization, and conversion of dimeric G-quadruplexes of HIV-1 integrase inhibitors by Electrospray ionization mass Spectrometry
作者: Li, Huihui1;  Yuan, Gu1;  Du, Daming1
刊名: JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
发表日期: 2008-04-01
DOI: 10.1016/j.jasms.2008.01.012
卷: 19, 期:4, 页:550-559
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences ;  Technology
类目[WOS]: Chemistry, Analytical ;  Chemistry, Physical ;  Spectroscopy
研究领域[WOS]: Chemistry ;  Spectroscopy
英文摘要: The dimeric G-quadruplex structures of d(GGGTGGGTGGGTGGGT) (SI) and d(GTGGTGGGTGGGTGGGT) (S2), the potent nanomolar HIV-1 integrase inhibitors, were detected by electrospray ionization mass spectrometry (ESI-MS) for the first time. The formation and conversion of the dimers were induced by NH4+, DNA concentration, pH, and the binding molecules. We directly observed the specific binding of a perylene derivative (TeL03) and hnhnIm beta Dp in one system consisting of the intramolecular and the dimeric G-quadruplexes of the HIV-1 integrase inhibitor, which suggested that Tel03 could shift the equilibrium to the dimeric G-quadruplex formation, while hnImIm beta Dp induces preferentially a structural change from the dimer to the intramolecular G-quadruplex. The results of this study indicated that TeL03 and ImImIm beta Dp favor the stabilizationof the dimeric G-quadruplex structures.
关键词[WOS]: STRUCTURAL-CHARACTERIZATION ;  DNA ;  OLIGONUCLEOTIDE ;  BINDING ;  SEQUENCE ;  STRANDS ;  DRUGS
语种: 英语
WOS记录号: WOS:000255091500010
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/140924
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Dept Chem Biol,Coll Chem & Mol Engn, Beijing 100871, Peoples R China

Recommended Citation:
Li, Huihui,Yuan, Gu,Du, Daming. Investigation of formation, recognition, stabilization, and conversion of dimeric G-quadruplexes of HIV-1 integrase inhibitors by Electrospray ionization mass Spectrometry[J]. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY,2008,19(4):550-559.
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