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Investigation of formation, recognition, stabilization, and conversion of dimeric G-quadruplexes of HIV-1 integrase inhibitors by Electrospray ionization mass Spectrometry
Li, Huihui; Yuan, Gu; Du, Daming
刊名JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
2008-04-01
DOI10.1016/j.jasms.2008.01.012
19期:4页:550-559
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences ; Technology
类目[WOS]Chemistry, Analytical ; Chemistry, Physical ; Spectroscopy
研究领域[WOS]Chemistry ; Spectroscopy
关键词[WOS]STRUCTURAL-CHARACTERIZATION ; DNA ; OLIGONUCLEOTIDE ; BINDING ; SEQUENCE ; STRANDS ; DRUGS
英文摘要The dimeric G-quadruplex structures of d(GGGTGGGTGGGTGGGT) (SI) and d(GTGGTGGGTGGGTGGGT) (S2), the potent nanomolar HIV-1 integrase inhibitors, were detected by electrospray ionization mass spectrometry (ESI-MS) for the first time. The formation and conversion of the dimers were induced by NH4+, DNA concentration, pH, and the binding molecules. We directly observed the specific binding of a perylene derivative (TeL03) and hnhnIm beta Dp in one system consisting of the intramolecular and the dimeric G-quadruplexes of the HIV-1 integrase inhibitor, which suggested that Tel03 could shift the equilibrium to the dimeric G-quadruplex formation, while hnImIm beta Dp induces preferentially a structural change from the dimer to the intramolecular G-quadruplex. The results of this study indicated that TeL03 and ImImIm beta Dp favor the stabilizationof the dimeric G-quadruplex structures.
语种英语
WOS记录号WOS:000255091500010
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文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/140924
专题中国科学院大连化学物理研究所
作者单位Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Dept Chem Biol,Coll Chem & Mol Engn, Beijing 100871, Peoples R China
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Li, Huihui,Yuan, Gu,Du, Daming. Investigation of formation, recognition, stabilization, and conversion of dimeric G-quadruplexes of HIV-1 integrase inhibitors by Electrospray ionization mass Spectrometry[J]. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY,2008,19(4):550-559.
APA Li, Huihui,Yuan, Gu,&Du, Daming.(2008).Investigation of formation, recognition, stabilization, and conversion of dimeric G-quadruplexes of HIV-1 integrase inhibitors by Electrospray ionization mass Spectrometry.JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY,19(4),550-559.
MLA Li, Huihui,et al."Investigation of formation, recognition, stabilization, and conversion of dimeric G-quadruplexes of HIV-1 integrase inhibitors by Electrospray ionization mass Spectrometry".JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY 19.4(2008):550-559.
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