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Efficient enzymatic regioselective benzoylation of 5-fluorouridine catalysed by Novozym 435
Wu, Jian1,2; Zong, Min-Hua1; Wu, Hong1; Lou, Wen-Yong1
KeywordNovozym 435 Regioselective Acylation 5-fluorouridine 5'-o-benzoyl-5-fluorouridine Vinyl Benzoate Co-solvent
Source PublicationJOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
2008-06-01
DOI10.1002/jctb.1874
Volume83Issue:6Pages:814-820
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences ; Technology
WOS SubjectBiotechnology & Applied Microbiology ; Chemistry, Multidisciplinary ; Engineering, Chemical
WOS Research AreaBiotechnology & Applied Microbiology ; Chemistry ; Engineering
WOS KeywordORGANIC-SOLVENTS ; WATER ACTIVITY ; ANTITUMOR-ACTIVITY ; NONAQUEOUS MEDIA ; LIPASE ; NUCLEOSIDES ; DERIVATIVES ; ACYLATION ; MILD ; 1-BETA-D-ARABINOFURANOSYLCYTOSINE
AbstractBACKGROUND: This work focuses on developing a mild, efficient and regioselective enzymatic procedure to synthesise 5'-O-benzoyl-5-fluorouridine, a more powerful antitumour drug than 5-fluorouridine itself, and examining the influences of several key variables on the reaction.
Language英语
WOS IDWOS:000256203400007
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/140972
Collection中国科学院大连化学物理研究所
Affiliation1.S China Univ Technol, Lab Appl Biocatalysis, Guangzhou 510640, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Wu, Jian,Zong, Min-Hua,Wu, Hong,et al. Efficient enzymatic regioselective benzoylation of 5-fluorouridine catalysed by Novozym 435[J]. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY,2008,83(6):814-820.
APA Wu, Jian,Zong, Min-Hua,Wu, Hong,&Lou, Wen-Yong.(2008).Efficient enzymatic regioselective benzoylation of 5-fluorouridine catalysed by Novozym 435.JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY,83(6),814-820.
MLA Wu, Jian,et al."Efficient enzymatic regioselective benzoylation of 5-fluorouridine catalysed by Novozym 435".JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY 83.6(2008):814-820.
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