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Profiling of yew hair roots from various species using ultra-performance liquid chromatography/electrospray ionization mass spectrometry
Ge, Guang-Bo1,2; Luan, Hong-Wei1,2; Zhang, Yan-Yan1,2; He, Yu-Qi3; Liu, Xing-Bao1; Yang, Li3; Wang, Zheng-Tao3; Yang, Ling1
刊名RAPID COMMUNICATIONS IN MASS SPECTROMETRY
2008-08-01
DOI10.1002/rcm.3616
22期:15页:2315-2323
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences ; Technology
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical ; Spectroscopy
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry ; Spectroscopy
关键词[WOS]HUMAN PLASMA ; QUANTITATIVE-ANALYSIS ; TAXUS-CHINENSIS ; CELL-CULTURES ; PACLITAXEL ; TAXOL ; METABOLITES ; CONSTITUENTS ; UPLC ; 10-DEACETYLPACLITAXEL
英文摘要An efficient and sensitive profiling approach to complex yew samples was developed using ultra-performance liquid chromatography/electrospray ionization mass spectrometry (UPLC/ESI-MS). The UPLC-based method displayed short analytical time and improved peak capability, as well as high sensitivity. The appropriate in-source collision-induced dissociation (CID) energy was employed to produce informative characteristic ions which could be used for stereochemical and sub-structural assignment of yew constituents. The method was successfully applied in the rapid screening of yew hair roots from various species, and 53 constituents including 47 taxoids were detected from partially purified root extract. Notably, C-7 hydroxytaxane stereoisomers could be identified based on their different fragment ions under the optimal profiling conditions. It was also observed that hair roots from different Taxus species exhibited nearly identical chemical distribution, indicating they had similar metabolic frameworks. Additionally, Taxus root resources also display benign medicinal perspective because they have relatively simple chemical profiles and possess high yields of valuable taxanes such as paclitaxel, cephalomannine, 10-deacetylpaclitaxel and 7-xylosyltaxanes. Copyright (c) 2008 John Wiley & Sons, Ltd.
语种英语
WOS记录号WOS:000258188400004
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/140988
专题中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China
3.Shanghai Univ Tradit Chinese Med, Minist Educ, Key Lab Standardizat Chinese Med, Shanghai, Peoples R China
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Ge, Guang-Bo,Luan, Hong-Wei,Zhang, Yan-Yan,et al. Profiling of yew hair roots from various species using ultra-performance liquid chromatography/electrospray ionization mass spectrometry[J]. RAPID COMMUNICATIONS IN MASS SPECTROMETRY,2008,22(15):2315-2323.
APA Ge, Guang-Bo.,Luan, Hong-Wei.,Zhang, Yan-Yan.,He, Yu-Qi.,Liu, Xing-Bao.,...&Yang, Ling.(2008).Profiling of yew hair roots from various species using ultra-performance liquid chromatography/electrospray ionization mass spectrometry.RAPID COMMUNICATIONS IN MASS SPECTROMETRY,22(15),2315-2323.
MLA Ge, Guang-Bo,et al."Profiling of yew hair roots from various species using ultra-performance liquid chromatography/electrospray ionization mass spectrometry".RAPID COMMUNICATIONS IN MASS SPECTROMETRY 22.15(2008):2315-2323.
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