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题名: Profiling of yew hair roots from various species using ultra-performance liquid chromatography/electrospray ionization mass spectrometry
作者: Ge, Guang-Bo1, 2;  Luan, Hong-Wei1, 2;  Zhang, Yan-Yan1, 2;  He, Yu-Qi3;  Liu, Xing-Bao1;  Yang, Li3;  Wang, Zheng-Tao3;  Yang, Ling1
刊名: RAPID COMMUNICATIONS IN MASS SPECTROMETRY
发表日期: 2008-08-01
DOI: 10.1002/rcm.3616
卷: 22, 期:15, 页:2315-2323
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences ;  Technology
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical ;  Spectroscopy
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry ;  Spectroscopy
英文摘要: An efficient and sensitive profiling approach to complex yew samples was developed using ultra-performance liquid chromatography/electrospray ionization mass spectrometry (UPLC/ESI-MS). The UPLC-based method displayed short analytical time and improved peak capability, as well as high sensitivity. The appropriate in-source collision-induced dissociation (CID) energy was employed to produce informative characteristic ions which could be used for stereochemical and sub-structural assignment of yew constituents. The method was successfully applied in the rapid screening of yew hair roots from various species, and 53 constituents including 47 taxoids were detected from partially purified root extract. Notably, C-7 hydroxytaxane stereoisomers could be identified based on their different fragment ions under the optimal profiling conditions. It was also observed that hair roots from different Taxus species exhibited nearly identical chemical distribution, indicating they had similar metabolic frameworks. Additionally, Taxus root resources also display benign medicinal perspective because they have relatively simple chemical profiles and possess high yields of valuable taxanes such as paclitaxel, cephalomannine, 10-deacetylpaclitaxel and 7-xylosyltaxanes. Copyright (c) 2008 John Wiley & Sons, Ltd.
关键词[WOS]: HUMAN PLASMA ;  QUANTITATIVE-ANALYSIS ;  TAXUS-CHINENSIS ;  CELL-CULTURES ;  PACLITAXEL ;  TAXOL ;  METABOLITES ;  CONSTITUENTS ;  UPLC ;  10-DEACETYLPACLITAXEL
语种: 英语
WOS记录号: WOS:000258188400004
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/140988
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China
3.Shanghai Univ Tradit Chinese Med, Minist Educ, Key Lab Standardizat Chinese Med, Shanghai, Peoples R China

Recommended Citation:
Ge, Guang-Bo,Luan, Hong-Wei,Zhang, Yan-Yan,et al. Profiling of yew hair roots from various species using ultra-performance liquid chromatography/electrospray ionization mass spectrometry[J]. RAPID COMMUNICATIONS IN MASS SPECTROMETRY,2008,22(15):2315-2323.
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