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题名: Molecularly imprinted polymer prepared with bonded beta-cyclodextrin and acrylamide on functionalized silica gel for selective recognition of tryptophan in aqueous media
作者: Qin, Lei1;  He, Xi-Wen1;  Li, Wen-You1;  Zhang, Yu-Kui1, 2
关键词: surface molecular imprinting technique ;  silica gel ;  beta-cyclodextrin ;  tryptophan ;  high-performance liquid chromatography ;  enantiomer separation
刊名: JOURNAL OF CHROMATOGRAPHY A
发表日期: 2008-04-11
DOI: 10.1016/j.chroma.2008.02.004
卷: 1187, 期:1-2, 页:94-102
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: A novel molecularly imprinted polymer (MIP) selective for tryptophan (Trp) was described where polymerization was performed in aqueous media. Three kinds of molecularly imprinted polymers were prepared with surface molecular imprinting technique on functionalized silica gel (F-silica gel). MIPs prepared using bonded beta-cyclodextrin (beta-CD) and acrylamide (AA), either separately or in combination have shown various recognition proper-ties. The results of adsorption experiments indicated that the selectivity of MIP, which was synthesized with bonded beta-CD and AA [MIP(1)], was superior to those obtained with AA [MIP(2)] or bonded beta-CD [MIP(3)]. In addition, the high-performance liquid chromatography (HPLC) column packed with MIP(1) could not only separate Trp from other aromatic amino acids, but also separate the template from its enantiomer in aqueous mobile phase. This study developed a new method for chiral amino acid separation and purification. (c) 2008 Elsevier B.V. All rights reserved.
关键词[WOS]: SOLID-PHASE EXTRACTION ;  PROTEIN RECOGNITION ;  AMINO-ACIDS ;  SEPARATION ;  RECEPTORS ;  NANOWIRES ;  BINDING ;  SITES ;  AMIDE ;  WATER
语种: 英语
WOS记录号: WOS:000255105300013
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/140999
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Nankai Univ, Dept Chem, Tianjin 300071, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116011, Peoples R China

Recommended Citation:
Qin, Lei,He, Xi-Wen,Li, Wen-You,et al. Molecularly imprinted polymer prepared with bonded beta-cyclodextrin and acrylamide on functionalized silica gel for selective recognition of tryptophan in aqueous media[J]. JOURNAL OF CHROMATOGRAPHY A,2008,1187(1-2):94-102.
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