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Curcumin Attenuates Acrylamide-induced Cytotoxicity and Genotoxicity in HepG2 Cells by ROS Scavenging
Cao, Jun1; Liu, Yong2; Jia, Li3; Jiang, Li-Ping1; Geng, Cheng-Yan1; Yao, Xiao-Feng1; Kong, Ying4; Jiang, Bao-Na5; Zhong, Lai-Fu1
关键词Curcumin Acrylamide Cytotoxicity Antigenotoxicity Antioxidant Hepg2 Cells
刊名JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
2008-12-24
DOI10.1021/jf8026827
56期:24页:12059-12063
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
研究领域[WOS]Agriculture ; Chemistry ; Food Science & Technology
关键词[WOS]HEPATOMA G2 CELLS ; DNA-DAMAGE ; GLYCIDAMIDE ; ELECTROPHORESIS ; TRANSFORMATION ; TOXICITY ; SINGLE ; OXYGEN ; ASSAY
英文摘要Acrylamide (AA), a proven rodent carcinogen, has recently been discovered in foods heated at high temperatures. This finding raises public health concerns. In our previous study, we found that AA caused DNA fragments and increase of reactive oxygen species (ROS) formation and induced genotoxicity and weak cytotoxicity in HepG2 cells. Presently, curcumin, a natural antioxidant compound present in turmeric was evaluated for its protective effects. The results showed that curcumin at the concentration of 2.5 mu g/mL significantly reduced AA-induced ROS production, DNA fragments, micronuclei formation, and cytotoxicity in HepG2 cells. The effect of PEG-catalase on protecting against AA-induced cytotoxicity suggests that AA-induced cytotoxicity is directly dependent on hydrogen peroxide production. These data suggest that curcumin could attenuate the cytotoxicity and genotoxicity induced by AA in HepG2 cells. The protection is probably mediated by an antioxidant protective mechanism. Consumption of curcumin may be a plausible way to prevent AA-mediated genotoxicity.
语种英语
WOS记录号WOS:000261802400071
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被引频次:67[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/141045
专题中国科学院大连化学物理研究所
作者单位1.Dalian Med Univ, Dept Toxicol, Dalian 116044, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Beijing 100864, Peoples R China
3.Dalian Med Univ, Coll Lab Med, Dalian 116044, Peoples R China
4.Dalian Med Univ, Dept Biochem & Mol Biol, Dalian 116044, Peoples R China
5.Dalian Med Univ, Off Res & Dev, Dalian 116044, Peoples R China
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Cao, Jun,Liu, Yong,Jia, Li,et al. Curcumin Attenuates Acrylamide-induced Cytotoxicity and Genotoxicity in HepG2 Cells by ROS Scavenging[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2008,56(24):12059-12063.
APA Cao, Jun.,Liu, Yong.,Jia, Li.,Jiang, Li-Ping.,Geng, Cheng-Yan.,...&Zhong, Lai-Fu.(2008).Curcumin Attenuates Acrylamide-induced Cytotoxicity and Genotoxicity in HepG2 Cells by ROS Scavenging.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,56(24),12059-12063.
MLA Cao, Jun,et al."Curcumin Attenuates Acrylamide-induced Cytotoxicity and Genotoxicity in HepG2 Cells by ROS Scavenging".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 56.24(2008):12059-12063.
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