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题名: Curcumin Attenuates Acrylamide-induced Cytotoxicity and Genotoxicity in HepG2 Cells by ROS Scavenging
作者: Cao, Jun1;  Liu, Yong2;  Jia, Li3;  Jiang, Li-Ping1;  Geng, Cheng-Yan1;  Yao, Xiao-Feng1;  Kong, Ying4;  Jiang, Bao-Na5;  Zhong, Lai-Fu1
关键词: Curcumin ;  acrylamide ;  cytotoxicity ;  antigenotoxicity ;  antioxidant ;  HepG2 cells
刊名: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
发表日期: 2008-12-24
DOI: 10.1021/jf8026827
卷: 56, 期:24, 页:12059-12063
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Agriculture, Multidisciplinary ;  Chemistry, Applied ;  Food Science & Technology
研究领域[WOS]: Agriculture ;  Chemistry ;  Food Science & Technology
英文摘要: Acrylamide (AA), a proven rodent carcinogen, has recently been discovered in foods heated at high temperatures. This finding raises public health concerns. In our previous study, we found that AA caused DNA fragments and increase of reactive oxygen species (ROS) formation and induced genotoxicity and weak cytotoxicity in HepG2 cells. Presently, curcumin, a natural antioxidant compound present in turmeric was evaluated for its protective effects. The results showed that curcumin at the concentration of 2.5 mu g/mL significantly reduced AA-induced ROS production, DNA fragments, micronuclei formation, and cytotoxicity in HepG2 cells. The effect of PEG-catalase on protecting against AA-induced cytotoxicity suggests that AA-induced cytotoxicity is directly dependent on hydrogen peroxide production. These data suggest that curcumin could attenuate the cytotoxicity and genotoxicity induced by AA in HepG2 cells. The protection is probably mediated by an antioxidant protective mechanism. Consumption of curcumin may be a plausible way to prevent AA-mediated genotoxicity.
关键词[WOS]: HEPATOMA G2 CELLS ;  DNA-DAMAGE ;  GLYCIDAMIDE ;  ELECTROPHORESIS ;  TRANSFORMATION ;  TOXICITY ;  SINGLE ;  OXYGEN ;  ASSAY
语种: 英语
WOS记录号: WOS:000261802400071
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141045
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Dalian Med Univ, Dept Toxicol, Dalian 116044, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Beijing 100864, Peoples R China
3.Dalian Med Univ, Coll Lab Med, Dalian 116044, Peoples R China
4.Dalian Med Univ, Dept Biochem & Mol Biol, Dalian 116044, Peoples R China
5.Dalian Med Univ, Off Res & Dev, Dalian 116044, Peoples R China

Recommended Citation:
Cao, Jun,Liu, Yong,Jia, Li,et al. Curcumin Attenuates Acrylamide-induced Cytotoxicity and Genotoxicity in HepG2 Cells by ROS Scavenging[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2008,56(24):12059-12063.
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