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题名: Multiple effects of a novel compound from Burkholderia cepacia against Candida albicans
作者: Li, Xin2, 3;  Quan, Chun-Shan1;  Yu, Hui-Ying4;  Fan, Sheng-Di1
关键词: Burkholderia cepacia ;  antifungal activity ;  Candida albicans ;  CF66I ;  cell wall ;  total lipids
刊名: FEMS MICROBIOLOGY LETTERS
发表日期: 2008-08-01
DOI: 10.1111/j.1574-6968.2008.01238.x
卷: 285, 期:2, 页:250-256
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Microbiology
研究领域[WOS]: Microbiology
英文摘要: A novel compound (named CF66I) produced by Burkholeria cepacia CF-66 strain was investigated for its antifungal activity against Candida albicans. This compound exhibited excellent antifungal activity in a dose- and time-dependent manner. Uptake analysis revealed that the compound preferentially acted against the fungal cell wall, and was also able to enter the cells. Transmission electron microscopy indicated that this compound caused loosening of the cell wall and a significant increase in the cell wall thickness was noted; however, no alterations were observed in the contents of the cell wall components. CF66I probably affected the normal assembly and integration of fungal cell wall components by interrupting the weak interactions between them, such as hydrogen and hydrophobic bonds. Propidium iodide (PI) staining indicated that on exposure to CF66I C. albicans cells became permeable to PI. Marked alterations in lipid and sterol contents were observed, and the major changes were a depletion of total lipids and ergosterol, concomitant with an increase in lanosterol content. These observations suggested that the novel compound CF66I may have considerable potential for development of a new class of antifungal agents.
关键词[WOS]: ANTIFUNGAL AGENTS ;  AMPHOTERICIN-B ;  CELL-WALL ;  LIPID-COMPOSITION ;  YEAST-CELLS ;  STEROL ;  CARBOHYDRATE ;  FLUCONAZOLE ;  INFECTIONS ;  INHIBITORS
语种: 英语
WOS记录号: WOS:000257659100016
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141050
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Dalian Nationalities Univ, Life Sci Coll, Dalian 116600, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China
3.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China
4.Tieling Forestry Bur, Dept Wildlife Conservat, Tieling, Peoples R China

Recommended Citation:
Li, Xin,Quan, Chun-Shan,Yu, Hui-Ying,et al. Multiple effects of a novel compound from Burkholderia cepacia against Candida albicans[J]. FEMS MICROBIOLOGY LETTERS,2008,285(2):250-256.
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