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题名: Functional analysis of cultured neural cells for evaluating cold/cool- and hot/warm-natured Chinese herbs
作者: Liu, Yan-Qiu1;  Cheng, Meng-Chun1;  Wang, Long-Xing1;  Zhao, Nan1;  Xiao, Hong-Bin1;  Wang, Zheng-Tao2
关键词: Chinese herbs ;  four properties ;  antioxidant activity ;  glucose uptake ;  norepinephrine
刊名: AMERICAN JOURNAL OF CHINESE MEDICINE
发表日期: 2008
卷: 36, 期:4, 页:771-781
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Integrative & Complementary Medicine ;  Medicine, General & Internal
研究领域[WOS]: Integrative & Complementary Medicine ;  General & Internal Medicine
英文摘要: Recently, modern scientific research has been required to understand pharmacological basis of traditional Chinese medicine (TCM) theory based on the ancient clinical experience, and to investigate the molecular mechanisms of action of Chinese herbs. Here, 20 Chinese herbs, classified into 4 properties (hot, warm, cold and cool) of TCM, were analyzed for their ability to exhibit antioxidant action, to enhance glucose uptake by murine microglia N9 cells, and to influence neurotransmitter norepinephrine (NE) release from rat pheochromocytoma PC12 cells. We found a generally protective effect of both hot/warm-natured and cold/cool-natured herbs against H(2)O(2)-induced N9 cell death, partially by elevating superoxide dismutase (SOD) activity. Glucose uptake was elevated after treatment with some hot/warm-natured herbs. In addition, most herbs with hot/warm nature tended to stimulate NE release, while such stimulatory effect was not observed in the herbs with cold/cool nature. Two cold/cool-natured herbs, Rhizoma coptidis and Radix scutellariae, even significantly suppressed the release. These results suggest that the distinct abilities of Chinese herbs to regulate neural cell functions appear to be correlated with their natures identified in traditional TCM theory, and may be a useful guide for their utility in neural degenerative diseases.
关键词[WOS]: ALZHEIMERS-DISEASE ;  OXIDATIVE STRESS ;  BETA ;  DEFICIENCY ;  DIAGNOSIS ;  MODEL
语种: 英语
WOS记录号: WOS:000258793200013
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141090
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Shanghai Univ TCM, Key Lab Standardizat Chinese Med, Minist Educ,Inst Chinese Mat Med, Shanghai R&D Ctr Standardizat Chinese Med, Shanghai 201203, Peoples R China

Recommended Citation:
Liu, Yan-Qiu,Cheng, Meng-Chun,Wang, Long-Xing,et al. Functional analysis of cultured neural cells for evaluating cold/cool- and hot/warm-natured Chinese herbs[J]. AMERICAN JOURNAL OF CHINESE MEDICINE,2008,36(4):771-781.
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