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题名: A study of the influence of cephalosporins on the microbial activity of E. coli by microcalorimetry
作者: Yang Li-Ni1, 2;  Sun Li-Xian1;  Xu Fen1;  Zhao Zong-Bao3;  Liang Jian-Guo4
关键词: microcalorimetry ;  inhibition fuction ;  cephalosporin ;  E. coli DH5 alpha
刊名: CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
发表日期: 2008-07-10
卷: 29, 期:7, 页:1412-1415
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
英文摘要: The effects of Cefoperazone Sodium(CFZ) and Cefoperazone Sodium & Sulbactain Sodium for injection(CFZ-SBT) on the metabolism of Escherichia coli(E. coli) DH5 alpha were studied by microcalorimetry. The microbial activity was recorded as power-time curves through an ampoule method with a TAM air isothermal microcalorimeter at 37 degrees C. The parameters such as the growth rate constant(k), inhibitory ratio(I), the maximum power output(P-m) and the time(t(m)) corresponding to the maximum power output were obtained. The lethal doses of CFZ and CFZ-SBT were calculated as 0.1 and 0.25 mu g/mL, respectively. Moreover, according to the relationship between k, P-m, t(m) and c, the conclusion could be made that the CFZ-SBT cannot improve the inhibitory effect on E. coli DH5 alpha in comparison with the CFZ.
关键词[WOS]: ESCHERICHIA-COLI ;  GROWTH ;  ANTIBIOTICS ;  DH5-ALPHA
语种: 英语
WOS记录号: WOS:000258092900027
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141141
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Mat & Thermochem Lab, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China
4.Hunan Inst Drug Detect, Changsha 410001, Peoples R China

Recommended Citation:
Yang Li-Ni,Sun Li-Xian,Xu Fen,et al. A study of the influence of cephalosporins on the microbial activity of E. coli by microcalorimetry[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2008,29(7):1412-1415.
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