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题名: Structural transition from the random coil to quadruplex of AG(3)(T(2)AG(3))(3) induced by Zn2+
作者: Wei, Chunying1;  Tang, Qian2;  Li, Can3
关键词: Zn2+ ;  G-quadruplexes ;  spectroscopy ;  structural transitions
刊名: BIOPHYSICAL CHEMISTRY
发表日期: 2008-02-01
DOI: 10.1016/j.bpc.2007.10.013
卷: 132, 期:2-3, 页:110-113
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemistry & Molecular Biology ;  Biophysics ;  Chemistry, Physical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Biophysics ;  Chemistry
英文摘要: Structures of G-quadruplex DNAs can be typically stabilized by monovalent cations such as K+, Na+. Some divalent and trivalent cations, such as Sr+, Pb2+, Tb3+ and Eu3+, can also induce the formation of G-quadruplex DNA. Here we show that Zn2+ can induce the human telomeric sequence AG(3)(T(2)AG(3))(3) to fold the G-quadruplex structure by UV absorbance difference spectra and circular dichroisin (CD) spectroscopy. At micromolar concentrations, the Zn2+-induced changes in the UV absorbance difference spectra and CD spectra are the characteristics of antiparallel G-quadruplexes although the long wavelength CD maximum is around 285 nm rather than the typical value of 295 nm. The binding stoichometry of Zn2+ per one AG(3)(T(2)AG(3))(3) molecule is four. To our knowledge, the structural transition of human telomeric sequence induced by Zn2+ was observed for the first time. (C) 2007 Elsevier B.V. All rights reserved.
关键词[WOS]: DNA STRUCTURES ;  COMPETITION ;  TELOMERASE ;  TETRAPLEX ;  SEQUENCE ;  APTAMER ;  BINDING ;  ION
语种: 英语
WOS记录号: WOS:000252487800006
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141164
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Shanxi Univ, Inst Mol Sci, Minist Educ, Key Lab Chem Biol & Mol Engn, Taiyuan 030006, Peoples R China
2.Dalian Univ Technol, Bioengn Coll, Dalian 116622, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China

Recommended Citation:
Wei, Chunying,Tang, Qian,Li, Can. Structural transition from the random coil to quadruplex of AG(3)(T(2)AG(3))(3) induced by Zn2+[J]. BIOPHYSICAL CHEMISTRY,2008,132(2-3):110-113.
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