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In vitro and in vivo characterization of alginate-chitosan-alginate artificial microcapsules for therapeutic oral delivery of live bacterial cells
Lin, Junzhang1,2; Yu, Weiting1; Liu, Xiudong3; Xie, Hongguo1,2; Wang, Wei1; Ma, Xiaojun1
关键词Alginate/chitosan/alginate Microcapslue Artificial Cell Live Bacterial Cells Oral Delivery
刊名JOURNAL OF BIOSCIENCE AND BIOENGINEERING
2008-06-01
DOI10.1263/jbb.105.660
105期:6页:660-665
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Biotechnology & Applied Microbiology ; Food Science & Technology
研究领域[WOS]Biotechnology & Applied Microbiology ; Food Science & Technology
关键词[WOS]GENETICALLY-ENGINEERED CELLS ; ESCHERICHIA-COLI ; GENE-THERAPY ; STABILITY ; ISLETS ; BEADS ; RATS ; UREA ; MICROENCAPSULATION ; IMMOBILIZATION
英文摘要Oral administration of artificial cell microcapsules entrapping live bacterial cells is a promising approach in disease therapy. However, the current technology of microcapsules limits this approach. In this study, alginate-chitosan-algin ate (ACA) microcapsules entrapping live bacterial cells were prepared with the purpose of oral delivery for therapy, and their in vitro and in vivo properties were investigated. Genetically engineered Escherichia coli DH5 were used as the model bacterial strain. ACA microcapsules remained intact and stable in simulated gastrointestinal fluid and the entrapped bacteria cells survived and grew normally. Moreover, ACA microcapsules were more stable than alginate-polylysine-alginate microcapsules in the rat gastrointestinal tract, which was attributed to the enhanced resistance of the ACA microcapsules to enzymatic digestion. Therefore, these results reinforce the potential of ACA microcapsules for the therapeutic oral delivery of live bacterial cells.
语种英语
WOS记录号WOS:000258565600013
引用统计
被引频次:31[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/141199
专题中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
3.Dalian Univ, Coll Environm & Chem Engn, Dalian 116622, Peoples R China
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GB/T 7714
Lin, Junzhang,Yu, Weiting,Liu, Xiudong,et al. In vitro and in vivo characterization of alginate-chitosan-alginate artificial microcapsules for therapeutic oral delivery of live bacterial cells[J]. JOURNAL OF BIOSCIENCE AND BIOENGINEERING,2008,105(6):660-665.
APA Lin, Junzhang,Yu, Weiting,Liu, Xiudong,Xie, Hongguo,Wang, Wei,&Ma, Xiaojun.(2008).In vitro and in vivo characterization of alginate-chitosan-alginate artificial microcapsules for therapeutic oral delivery of live bacterial cells.JOURNAL OF BIOSCIENCE AND BIOENGINEERING,105(6),660-665.
MLA Lin, Junzhang,et al."In vitro and in vivo characterization of alginate-chitosan-alginate artificial microcapsules for therapeutic oral delivery of live bacterial cells".JOURNAL OF BIOSCIENCE AND BIOENGINEERING 105.6(2008):660-665.
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