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题名: In vitro and in vivo characterization of alginate-chitosan-alginate artificial microcapsules for therapeutic oral delivery of live bacterial cells
作者: Lin, Junzhang1, 2;  Yu, Weiting1;  Liu, Xiudong3;  Xie, Hongguo1, 2;  Wang, Wei1;  Ma, Xiaojun1
关键词: alginate/chitosan/alginate microcapslue ;  artificial cell ;  live bacterial cells ;  oral delivery
刊名: JOURNAL OF BIOSCIENCE AND BIOENGINEERING
发表日期: 2008-06-01
DOI: 10.1263/jbb.105.660
卷: 105, 期:6, 页:660-665
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biotechnology & Applied Microbiology ;  Food Science & Technology
研究领域[WOS]: Biotechnology & Applied Microbiology ;  Food Science & Technology
英文摘要: Oral administration of artificial cell microcapsules entrapping live bacterial cells is a promising approach in disease therapy. However, the current technology of microcapsules limits this approach. In this study, alginate-chitosan-algin ate (ACA) microcapsules entrapping live bacterial cells were prepared with the purpose of oral delivery for therapy, and their in vitro and in vivo properties were investigated. Genetically engineered Escherichia coli DH5 were used as the model bacterial strain. ACA microcapsules remained intact and stable in simulated gastrointestinal fluid and the entrapped bacteria cells survived and grew normally. Moreover, ACA microcapsules were more stable than alginate-polylysine-alginate microcapsules in the rat gastrointestinal tract, which was attributed to the enhanced resistance of the ACA microcapsules to enzymatic digestion. Therefore, these results reinforce the potential of ACA microcapsules for the therapeutic oral delivery of live bacterial cells.
关键词[WOS]: GENETICALLY-ENGINEERED CELLS ;  ESCHERICHIA-COLI ;  GENE-THERAPY ;  STABILITY ;  ISLETS ;  BEADS ;  RATS ;  UREA ;  MICROENCAPSULATION ;  IMMOBILIZATION
语种: 英语
WOS记录号: WOS:000258565600013
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141199
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
3.Dalian Univ, Coll Environm & Chem Engn, Dalian 116622, Peoples R China

Recommended Citation:
Lin, Junzhang,Yu, Weiting,Liu, Xiudong,et al. In vitro and in vivo characterization of alginate-chitosan-alginate artificial microcapsules for therapeutic oral delivery of live bacterial cells[J]. JOURNAL OF BIOSCIENCE AND BIOENGINEERING,2008,105(6):660-665.
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