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题名: Polyelectrolyte microcapsules prepared by alginate and chitosan for biomedical application
作者: Liu Xiudong1, 2;  Yu Weiting1;  Wang Wei1;  Xiong Ying1;  Ma Xiaojun1;  Yuan Quan1
关键词: alginate ;  chitosan ;  polyelectrolyte ;  microcapsule ;  cell transplantation ;  cell culture ;  drug delivery
刊名: PROGRESS IN CHEMISTRY
发表日期: 2008
卷: 20, 期:1, 页:126-139
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
英文摘要: This review highlights the progress in the structure and chemical properties of natural polysaccharides (alginate and chitosan) including gel formation, biocompatibility, biodegradability and mild reaction ability; preparation technologies of microcapsules (polyelectrolyte complexation/polyelectrolyle layer-by-layer self assembly), and the evaluation methods on microcapsule's mechanical and permeable properties; microcapsules entrapping cells secreting therapeutics (such as insulin and dopamine) or decomposing toxic metabolites ( such as urea) in vivo, microcapsules serving as three-dimensional drug screening systems and microenvironment for the proliferation and differentiation of stem cells, microcapsules serving as the drug carriers for controlled release. Finally, the challenge and problem for the development of microcapsules are discussed.
关键词[WOS]: EMULSIFICATION INTERNAL GELATION ;  TERM IMMUNOISOLATED TRANSPLANTATION ;  COLI DH5 CELLS ;  PANCREATIC-ISLETS ;  PROTEIN RELEASE ;  IN-VITRO ;  MICROENCAPSULATED HEPATOCYTES ;  SEMIPERMEABLE MICROCAPSULES ;  ENCAPSULATED HEPATOCYTES ;  COACERVATE MICROCAPSULES
语种: 英语
WOS记录号: WOS:000253022000016
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141215
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Dalian Univ Technol, Coll Environm & Chem Engn, Dalian 116622, Peoples R China

Recommended Citation:
Liu Xiudong,Yu Weiting,Wang Wei,et al. Polyelectrolyte microcapsules prepared by alginate and chitosan for biomedical application[J]. PROGRESS IN CHEMISTRY,2008,20(1):126-139.
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