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题名: A facile "liquid-molding'' method to fabricate PDMS microdevices with 3-dimensional channel topography
作者: Liu, Xin2;  Wang, Qi1;  Qin, Jianhua2;  Lin, Bingcheng2
刊名: LAB ON A CHIP
发表日期: 2009
DOI: 10.1039/b818721e
卷: 9, 期:9, 页:1200-1205
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Multidisciplinary ;  Nanoscience & Nanotechnology
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry ;  Science & Technology - Other Topics
英文摘要: This work deals with a facile "liquid-molding'' technology to fabricate PDMS microdevices with complex structured microchannels, the main procedures of which involves: (1) Photo-lithographically fabricating chemical micropatterns of hydrogels on silanized glass substrates to form heterogeneous hydrophilic/hydrophobic surfaces; (2) Fabricating stable 3D surface relief patterns of a liquid via dip-coating the hydrogel patterned substrate in a polar solution; (3) Fabricating PDMS microfluidic devices via a slightly modified replica molding procedure, using a liquid patterned substrate as the molding template. In addition to its simplicity compared to conventional microfabrication methods, this technology produces microchannels with 3D surface topography, which allows for more flexibility in device design and applications. We discuss the main features of the liquid-molding method as well as the structural characteristics of liquid-molded microchannels. We demonstrate the potential application of these "liquid-molded'' PDMS (LM-PDMS) devices by designing a cell trapping microdevice that is capable of trapping multiple or individual cells through simple operation procedures.
关键词[WOS]: SOFT LITHOGRAPHY ;  CELLS ;  POLY(DIMETHYLSILOXANE) ;  SYSTEMS ;  DEVICE
语种: 英语
WOS记录号: WOS:000265223200007
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141272
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Dalian Med Univ, Hosp Affiliated 2, Dalian, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Grad Sch, Dalian, Peoples R China

Recommended Citation:
Liu, Xin,Wang, Qi,Qin, Jianhua,et al. A facile "liquid-molding'' method to fabricate PDMS microdevices with 3-dimensional channel topography[J]. LAB ON A CHIP,2009,9(9):1200-1205.
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