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A facile "liquid-molding'' method to fabricate PDMS microdevices with 3-dimensional channel topography
Liu, Xin2; Wang, Qi1; Qin, Jianhua2; Lin, Bingcheng2
刊名LAB ON A CHIP
2009
DOI10.1039/b818721e
9期:9页:1200-1205
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Biochemical Research Methods ; Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry ; Science & Technology - Other Topics
关键词[WOS]SOFT LITHOGRAPHY ; CELLS ; POLY(DIMETHYLSILOXANE) ; SYSTEMS ; DEVICE
英文摘要This work deals with a facile "liquid-molding'' technology to fabricate PDMS microdevices with complex structured microchannels, the main procedures of which involves: (1) Photo-lithographically fabricating chemical micropatterns of hydrogels on silanized glass substrates to form heterogeneous hydrophilic/hydrophobic surfaces; (2) Fabricating stable 3D surface relief patterns of a liquid via dip-coating the hydrogel patterned substrate in a polar solution; (3) Fabricating PDMS microfluidic devices via a slightly modified replica molding procedure, using a liquid patterned substrate as the molding template. In addition to its simplicity compared to conventional microfabrication methods, this technology produces microchannels with 3D surface topography, which allows for more flexibility in device design and applications. We discuss the main features of the liquid-molding method as well as the structural characteristics of liquid-molded microchannels. We demonstrate the potential application of these "liquid-molded'' PDMS (LM-PDMS) devices by designing a cell trapping microdevice that is capable of trapping multiple or individual cells through simple operation procedures.
语种英语
WOS记录号WOS:000265223200007
引用统计
被引频次:34[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/141272
专题中国科学院大连化学物理研究所
作者单位1.Dalian Med Univ, Hosp Affiliated 2, Dalian, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Grad Sch, Dalian, Peoples R China
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GB/T 7714
Liu, Xin,Wang, Qi,Qin, Jianhua,et al. A facile "liquid-molding'' method to fabricate PDMS microdevices with 3-dimensional channel topography[J]. LAB ON A CHIP,2009,9(9):1200-1205.
APA Liu, Xin,Wang, Qi,Qin, Jianhua,&Lin, Bingcheng.(2009).A facile "liquid-molding'' method to fabricate PDMS microdevices with 3-dimensional channel topography.LAB ON A CHIP,9(9),1200-1205.
MLA Liu, Xin,et al."A facile "liquid-molding'' method to fabricate PDMS microdevices with 3-dimensional channel topography".LAB ON A CHIP 9.9(2009):1200-1205.
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