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题名: Preparation of novel bovine hemoglobin surface-imprinted polystyrene nanoparticles with magnetic susceptibility
作者: Li Lin1, 2;  He XiWen1;  Chen LangXing1;  Zhang YuKui1, 3
关键词: magnetic nanoparticles ;  protein molecular imprinting ;  poly(3-aminophenylboronic acid) thin films ;  selective adsorption
刊名: SCIENCE IN CHINA SERIES B-CHEMISTRY
发表日期: 2009-09-01
DOI: 10.1007/s11426-009-0182-0
卷: 52, 期:9, 页:1402-1411
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
英文摘要: In this research, a surface imprinting strategy has been adopted in protein imprinting. Bovine hemoglobin surface-imprinted polystyrene (PS) nanoparticles with magnetic susceptibility have been synthesized through multistage core-shell polymerization system using 3-aminophenylboronic acid (APBA) as functional and cross-linking monomers. Superparamagnetic molecularly imprinted polystyrene nanospheres with poly(APBA) thin films have been synthesized and used for the first time for protein molecular imprinting in an aqueous solution. The magnetic susceptibility is imparted through the successful encapsulation of Fe(3)O(4) nanoparticles. The morphology, adsorption, and recognition properties of superparamagnetic molecularly imprinted polymers (MIPs) have been investigated using transmission electron microscopy, X-ray diffraction, thermogravimetric analysis, and vibrating sample magnetometer. Rebinding experimental results show that poly(APBA) MIPs-coated superparamagnetic PS nanoparticles have high adsorption capacity for template protein bovine hemoglobin and comparatively low nonspecific adsorption. The imprinted superparamagnetic nanoparticles could easily reach the adsorption equilibrium and achieve magnetic separation in an external magnetic field, thus avoiding some problems of the bulk polymer.
关键词[WOS]: IRON-OXIDE NANOPARTICLES ;  PROTEIN RECOGNITION ;  SERUM-ALBUMIN ;  THIN-FILMS ;  POLYMERS ;  MICROSPHERES ;  ADSORPTION ;  SEPARATION ;  BINDING ;  BEADS
语种: 英语
WOS记录号: WOS:000270191100016
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141318
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Nankai Univ, Coll Chem, Tianjin 300071, Peoples R China
2.Nankai Univ, Coll Pharmaceut Sci, Tianjin 300071, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116011, Peoples R China

Recommended Citation:
Li Lin,He XiWen,Chen LangXing,et al. Preparation of novel bovine hemoglobin surface-imprinted polystyrene nanoparticles with magnetic susceptibility[J]. SCIENCE IN CHINA SERIES B-CHEMISTRY,2009,52(9):1402-1411.
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