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题名: Retention properties of novel beta-CD bonded stationary phases in reversed-phase HPLC mode
作者: Zhao, Yanyan1;  Guo, Zhimou1;  Zhang, Yongping2;  Xue, Xingya1;  Xu, Qing1;  Li, Xiuling1;  Liang, Xinmiao1, 2;  Zhang, Yukui1
关键词: beta-CD ;  Bonded stationary phase ;  Retention property ;  LSERs
刊名: TALANTA
发表日期: 2009-05-15
DOI: 10.1016/j.talanta.2008.12.066
卷: 78, 期:3, 页:916-921
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: With the given special Structures, the CD bonded stationary phases are expected to have complementary retention Properties with conventional C18 stationary phase, which will be helpful to enhance the polar selectivity in RP mode separation. In this work, two beta-cyclodextrin (beta-CD) bonded stationary phases for reversed-phase HPLC, including 1, 12-dodecyldiol linked beta-CD stationary phase (CD1) and olio (ethylene glycol) (OEG) linked beta-CD stationary phase (CD2), have been synthesized via click chemistry. The resulting materials were characterized with FT-IR and elemental analysis, which proved the successful immobilization of ligands. The similarities and differences in retention characteristics between the CD and C18 stationary phases have been elucidated by using comparative linear solvation energy relationships (LSERs). The force related to Solute McGowan Volume has no significant difference, while the hydrogen bonding and dipolar interactions between solutes and CD stationary phases are stronger than between solutes and C18, which is attributed to the special structures (CD and triazole groups) of CD stationary phases. Chemical origins are interpreted by comparison between CD1 and CD2. Similar dispersive interactions of CD1 and CD2 are attributed to their similar length of spacer arms. CD2 which contains OEG spacer arm has relative weaker HBD acidity but stronger HBA basicity. CD stationary phases display no serious different methylene selectivity and higher polar selectivity than in the case of C18. Higher acid selectivity and lower basic selectivity are observed on CD2 than on CD1. Distinctive retention properties and good complementary separation selectivity to C18 make I he novel CD bonded stationary phases available for more application in RPLC. (C) 2009 Elsevier B.V. All rights reserved.
关键词[WOS]: PERFORMANCE LIQUID-CHROMATOGRAPHY ;  SOLVATION ENERGY RELATIONSHIPS ;  CLICK-CHEMISTRY ;  CYCLODEXTRIN DERIVATIVES ;  FACILE IMMOBILIZATION ;  AROMATIC-COMPOUNDS ;  CHIRAL SEPARATION ;  SILICA ;  SELECTIVITY ;  MECHANISM
语种: 英语
WOS记录号: WOS:000264976600045
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141320
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Key Lab Separat Sci Analyt Chem, Dalian Inst Chem Phys, Grad Sch, Dalian 116023, Peoples R China
2.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

Recommended Citation:
Zhao, Yanyan,Guo, Zhimou,Zhang, Yongping,et al. Retention properties of novel beta-CD bonded stationary phases in reversed-phase HPLC mode[J]. TALANTA,2009,78(3):916-921.
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