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题名: The biological routes of gene delivery mediated by lipid-based non-viral vectors
作者: Duan, Yan1, 2, 3;  Zhang, Shubiao1;  Wang, Bing1;  Yang, Baoling1;  Zhi, Defu1
关键词: gene delivery ;  non-viral vectors ;  technology ;  trafficking
刊名: EXPERT OPINION ON DRUG DELIVERY
发表日期: 2009-12-01
DOI: 10.1517/17425240903287153
卷: 6, 期:12, 页:1351-1361
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
英文摘要: Cationic lipid/DNA complexes (lipoplexes) represent an attractive alternative transfection in vitro and in vivo but still suffer from relatively low efficiency. Comprehension of the interactions between vectors and DNA as well as cellular pathways and mechanisms in DNA entry into cells and ultimately nuclei will lead to the design of better adapted non-viral vectors for gene therapy applications. Here, some recent developments in the field on the pathways and mechanisms involved in lipoplex-mediated transfection are discussed. The techniques that are widely used to study the mechanism of gene delivery are also discussed.
关键词[WOS]: CLATHRIN-INDEPENDENT ENDOCYTOSIS ;  NUCLEAR-LOCALIZATION SIGNAL ;  MAMMALIAN-CELLS OCCURS ;  CATIONIC LIPOSOMES ;  IN-VITRO ;  ELECTRON-MICROSCOPY ;  PHYSICOCHEMICAL CHARACTERIZATION ;  ENDOTHELIAL-CELLS ;  DNA TRANSFECTION ;  MITOTIC-ACTIVITY
语种: 英语
WOS记录号: WOS:000272988000007
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141337
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Dalian Nationalities Univ, Coll Life Sci, SEAC ME Key Lab Biotechnol & Bioresources Utiliza, Dalian 116600, Liaoning, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China
3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China

Recommended Citation:
Duan, Yan,Zhang, Shubiao,Wang, Bing,et al. The biological routes of gene delivery mediated by lipid-based non-viral vectors[J]. EXPERT OPINION ON DRUG DELIVERY,2009,6(12):1351-1361.
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