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A splicing model-based DNA-computing approach on microfluidic chip
Xie, Hua1,2; Li, Bowei1,2; Qin, Jianhua1; Huang, Zhende3; Zhu, Yisheng3; Lin, Bingcheng1
关键词Automaton Dna Computing Microfluidic Chip Splicing Model
刊名ELECTROPHORESIS
2009-10-01
DOI10.1002/elps.200900323
30期:20页:3514-3518
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]FRAGMENT ANALYSIS ; SURFACES ; COMPUTATION ; MICRODEVICE
英文摘要DNA computing is a new computation form based on DNA biochemical reactions, which is mainly composed of sticker and splicing computation models. In this work, a microfluidic chip-based approach was established for splicing model-based DNA computing. A finite automaton with two input symbols (a, b) and three states (S0, S1, and S2) was applied in the pattern recognition for isosceles triangles. The DNA computation processes of automaton were realized through DNA digestion, ligation, DNA separation, and detection on the microfluidic chip. The established approach is efficient, controllable, and easy to integrate, which paves the way for the building of complete biomolecular computers in the future.
语种英语
WOS记录号WOS:000271573400003
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/141374
专题中国科学院大连化学物理研究所
作者单位1.Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
3.Shanghai Jiao Tong Univ, Dept Biomed Engn, Shanghai 200030, Peoples R China
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GB/T 7714
Xie, Hua,Li, Bowei,Qin, Jianhua,et al. A splicing model-based DNA-computing approach on microfluidic chip[J]. ELECTROPHORESIS,2009,30(20):3514-3518.
APA Xie, Hua,Li, Bowei,Qin, Jianhua,Huang, Zhende,Zhu, Yisheng,&Lin, Bingcheng.(2009).A splicing model-based DNA-computing approach on microfluidic chip.ELECTROPHORESIS,30(20),3514-3518.
MLA Xie, Hua,et al."A splicing model-based DNA-computing approach on microfluidic chip".ELECTROPHORESIS 30.20(2009):3514-3518.
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