DICP OpenIR
A splicing model-based DNA-computing approach on microfluidic chip
Xie, Hua1,2; Li, Bowei1,2; Qin, Jianhua1; Huang, Zhende3; Zhu, Yisheng3; Lin, Bingcheng1
KeywordAutomaton Dna Computing Microfluidic Chip Splicing Model
Source PublicationELECTROPHORESIS
2009-10-01
DOI10.1002/elps.200900323
Volume30Issue:20Pages:3514-3518
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectBiochemical Research Methods ; Chemistry, Analytical
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS KeywordFRAGMENT ANALYSIS ; SURFACES ; COMPUTATION ; MICRODEVICE
AbstractDNA computing is a new computation form based on DNA biochemical reactions, which is mainly composed of sticker and splicing computation models. In this work, a microfluidic chip-based approach was established for splicing model-based DNA computing. A finite automaton with two input symbols (a, b) and three states (S0, S1, and S2) was applied in the pattern recognition for isosceles triangles. The DNA computation processes of automaton were realized through DNA digestion, ligation, DNA separation, and detection on the microfluidic chip. The established approach is efficient, controllable, and easy to integrate, which paves the way for the building of complete biomolecular computers in the future.
Language英语
WOS IDWOS:000271573400003
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/141374
Collection中国科学院大连化学物理研究所
Affiliation1.Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
3.Shanghai Jiao Tong Univ, Dept Biomed Engn, Shanghai 200030, Peoples R China
Recommended Citation
GB/T 7714
Xie, Hua,Li, Bowei,Qin, Jianhua,et al. A splicing model-based DNA-computing approach on microfluidic chip[J]. ELECTROPHORESIS,2009,30(20):3514-3518.
APA Xie, Hua,Li, Bowei,Qin, Jianhua,Huang, Zhende,Zhu, Yisheng,&Lin, Bingcheng.(2009).A splicing model-based DNA-computing approach on microfluidic chip.ELECTROPHORESIS,30(20),3514-3518.
MLA Xie, Hua,et al."A splicing model-based DNA-computing approach on microfluidic chip".ELECTROPHORESIS 30.20(2009):3514-3518.
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