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题名: A study of the interaction between enantiomers of zolmitriptan and hydroxypropyl-beta-cyclodextrin by capillary electrophoresis
作者: Pang, Nannan1;  Zhang, Zhengxiang1;  Bai, Yu1;  Liu, Huwei1
关键词: Binding constant ;  Capillary zone electrophoresis ;  Enantioseparation ;  Zolmitriptan ;  Cyclodextrin
刊名: ANALYTICAL AND BIOANALYTICAL CHEMISTRY
发表日期: 2009
DOI: 10.1007/s00216-008-2446-5
卷: 393, 期:1, 页:313-320
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: The enantioresolution of zolmitriptan was performed using cyclodextrin (CD)-modified capillary zone electrophoresis (CZE) with hydroxypropyl-beta-CD (HP-beta-CD) as the chiral selector. The influence of experimental conditions on the enantioseparation of zolmitriptan, such as pH, temperature, applied voltage, and concentrations of running electrolyte and CD, was systematically investigated, obtaining a baseline separation of two enantiomers by the use of a 25 mM sodium dihydrogen phosphate (SDPH) running electrolyte (pH 2.4) containing 30 mM HP-beta-CD at 15 degrees C. Binding constants for each enantiomer-HP-beta-CD pair at different temperatures, as well as thermodynamic parameters for binding, were calculated. A nonlinear van't Hoff plot was obtained, indicating that the thermodynamic parameters of complexation were temperature-dependent for zolmitriptan enantiomers. The significant contribution of the enthalpy difference to the Gibbs free energy change suggested a stereomeric barrier mechanism for chiral recognition.
关键词[WOS]: PERFORMANCE LIQUID-CHROMATOGRAPHY ;  APPARENT BINDING CONSTANTS ;  TANDEM MASS-SPECTROMETRY ;  CHIRAL LC-METHOD ;  HUMAN PLASMA ;  THERMODYNAMIC PARAMETERS ;  FLUORESCENCE DETECTION ;  ZONE-ELECTROPHORESIS ;  N-DESMETHYLZOLMITRIPTAN ;  ASSOCIATION CONSTANTS
语种: 英语
WOS记录号: WOS:000261831000035
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141384
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Inst Analyt Chem,Coll Chem & Mol Engn, Beijing 100871, Peoples R China

Recommended Citation:
Pang, Nannan,Zhang, Zhengxiang,Bai, Yu,et al. A study of the interaction between enantiomers of zolmitriptan and hydroxypropyl-beta-cyclodextrin by capillary electrophoresis[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2009,393(1):313-320.
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