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A study of the interaction between enantiomers of zolmitriptan and hydroxypropyl-beta-cyclodextrin by capillary electrophoresis
Pang, Nannan; Zhang, Zhengxiang; Bai, Yu; Liu, Huwei
关键词Binding Constant Capillary Zone Electrophoresis Enantioseparation Zolmitriptan Cyclodextrin
刊名ANALYTICAL AND BIOANALYTICAL CHEMISTRY
2009
DOI10.1007/s00216-008-2446-5
393期:1页:313-320
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]PERFORMANCE LIQUID-CHROMATOGRAPHY ; APPARENT BINDING CONSTANTS ; TANDEM MASS-SPECTROMETRY ; CHIRAL LC-METHOD ; HUMAN PLASMA ; THERMODYNAMIC PARAMETERS ; FLUORESCENCE DETECTION ; ZONE-ELECTROPHORESIS ; N-DESMETHYLZOLMITRIPTAN ; ASSOCIATION CONSTANTS
英文摘要The enantioresolution of zolmitriptan was performed using cyclodextrin (CD)-modified capillary zone electrophoresis (CZE) with hydroxypropyl-beta-CD (HP-beta-CD) as the chiral selector. The influence of experimental conditions on the enantioseparation of zolmitriptan, such as pH, temperature, applied voltage, and concentrations of running electrolyte and CD, was systematically investigated, obtaining a baseline separation of two enantiomers by the use of a 25 mM sodium dihydrogen phosphate (SDPH) running electrolyte (pH 2.4) containing 30 mM HP-beta-CD at 15 degrees C. Binding constants for each enantiomer-HP-beta-CD pair at different temperatures, as well as thermodynamic parameters for binding, were calculated. A nonlinear van't Hoff plot was obtained, indicating that the thermodynamic parameters of complexation were temperature-dependent for zolmitriptan enantiomers. The significant contribution of the enthalpy difference to the Gibbs free energy change suggested a stereomeric barrier mechanism for chiral recognition.
语种英语
WOS记录号WOS:000261831000035
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被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/141384
专题中国科学院大连化学物理研究所
作者单位Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Inst Analyt Chem,Coll Chem & Mol Engn, Beijing 100871, Peoples R China
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Pang, Nannan,Zhang, Zhengxiang,Bai, Yu,et al. A study of the interaction between enantiomers of zolmitriptan and hydroxypropyl-beta-cyclodextrin by capillary electrophoresis[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2009,393(1):313-320.
APA Pang, Nannan,Zhang, Zhengxiang,Bai, Yu,&Liu, Huwei.(2009).A study of the interaction between enantiomers of zolmitriptan and hydroxypropyl-beta-cyclodextrin by capillary electrophoresis.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,393(1),313-320.
MLA Pang, Nannan,et al."A study of the interaction between enantiomers of zolmitriptan and hydroxypropyl-beta-cyclodextrin by capillary electrophoresis".ANALYTICAL AND BIOANALYTICAL CHEMISTRY 393.1(2009):313-320.
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