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题名: Bioconversion of red ginseng saponins in the gastro-intestinal tract in vitro model studied by high-performance liquid chromatography-high resolution Fourier transform ion cyclotron resonance mass spectrometry
作者: Kong, Hongwei1, 2;  Wang, Mei3, 4;  Venema, Koen4;  Maathuis, Annet4;  van der Heijden, Rob1;  van der Greef, Jan1, 4;  Xu, Guowang2;  Hankemeier, Thomas1
关键词: Panax ginseng ;  HPLC-FTICR-MS ;  Ginsenoside ;  Intestinal bacteria ;  Metabolism ;  TNO gastro-intestinal model (TIM) ;  Acidic hydrolysis ;  Metabolite profiling
刊名: JOURNAL OF CHROMATOGRAPHY A
发表日期: 2009-03-13
DOI: 10.1016/j.chroma.2008.11.030
卷: 1216, 期:11, 页:2195-2203
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: A high-performance liquid chromatography-high resolution Fourier transform ion cyclotron resonance mass spectrometry (HPLC-FTICR-MS) method was developed to investigate the metabolism of ginsenosides in in vitro models of the gastro-intestinal tract. The metabolites were identified by high-resolution tandem mass spectrometry. Degradation and bioconversion routes of the different ginsenosides at acidic (gastric) conditions and in the presence of intestinal microbiota were elaborated. Besides hydrolysis (deglycosylation) also hydration reactions Occurred at acidic conditions. The results illustrate the value of metabolite profiling by HPLC-FTICR-MS for understanding of the mechanisms in bioavailability of herbal drugs and their metabolites. (C) 2008 Elsevier B.V. All rights reserved.
关键词[WOS]: HUMAN INTESTINAL BACTERIA ;  PANAX-GINSENG ;  GINSENOSIDES ;  METABOLISM ;  IDENTIFICATION ;  ACTIVATION ;  ROOTS ;  RH-2 ;  RB-1 ;  RAT
语种: 英语
WOS记录号: WOS:000264226500030
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141396
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Leiden Univ, Leiden Amsterdam Ctr Drug Res, Div Analyt Biosci, NL-2300 RA Leiden, Netherlands
2.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China
3.SU BioMed, NL-3700 AJ Zeist, Netherlands
4.TNO Netherlands Org Appl Sci Res, Leiden, Netherlands

Recommended Citation:
Kong, Hongwei,Wang, Mei,Venema, Koen,et al. Bioconversion of red ginseng saponins in the gastro-intestinal tract in vitro model studied by high-performance liquid chromatography-high resolution Fourier transform ion cyclotron resonance mass spectrometry[J]. JOURNAL OF CHROMATOGRAPHY A,2009,1216(11):2195-2203.
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