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题名: Determination of fentanyl in human breath by solid-phase microextraction and gas chromatography-mass spectrometry
作者: Wang, Changsong1;  Li, Enyou1;  Xu, Guowang2;  Wang, Hui1;  Gong, Yulei1;  Li, Peng1;  Liu, Shujuan1;  He, Ying1
关键词: Fentanyl ;  Breath ;  Solid-phase microextraction ;  Gas chromatography-mass spectrometry
刊名: MICROCHEMICAL JOURNAL
发表日期: 2009-03-01
DOI: 10.1016/j.microc.2008.09.002
卷: 91, 期:2, 页:149-152
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: Fentanyl, a kind of intravenous narcotic analgesic, is widely used in clinical anesthesia. As a potential pollution, it was detected in both the air of the cardiothoracic operating room and patients' expiratory circuit. However, whether the fentanyl in patients' expiratory circuit is exhaled by patients is unknown. In this study, breath samples were taken from the expiratory circuits of anesthetic machine linked to the patients who received intravenous fentanyl, a solid-phase microextraction (SPME) coupled with gas chromatography-mass spectrometry (GC-MS) method was developed to detect and quantify fentanyl in breath samples. The parameters influencing adsorption (extraction time, temperature,) and desorption (desorption time) of the analyte on the fiber were investigated and validated for method development. The developed method was proved to be simple, easy, and inexpensive and offer high sensitivity and reproducibility. Linear range was obtained from 0.05 ng/mL to 0.8 ng/mL. The limit of detection was 0.01 ng/mL while an interday precision of less than 12.13% (n = 5) could be achieved. Six patients were involved in this study; results showed presence of fentanyl in the breath of patients who received intravenous fentanyl, and fentanyl concentrations in breath varied from 6.00 to 20.89 pg/mL. In conclusion, fentanyl can be exhaled by patients who received intravenous fentanyl. (C) 2008 Elsevier B.V. All rights reserved.
关键词[WOS]: TRANSDERMAL PATCHES ;  HUMAN PLASMA ;  SAMPLES ;  SUFENTANIL ;  URINE
语种: 英语
WOS记录号: WOS:000264238000001
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141397
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Harbin Med Coll, Dept Anesthesiol, Affiliated Hosp 1, Harbin 150001, Heilongjiang, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Liaoning, Peoples R China

Recommended Citation:
Wang, Changsong,Li, Enyou,Xu, Guowang,et al. Determination of fentanyl in human breath by solid-phase microextraction and gas chromatography-mass spectrometry[J]. MICROCHEMICAL JOURNAL,2009,91(2):149-152.
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