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题名: Interactions between human cytochrome P450 enzymes and steroids: physiological and pharmacological implications
作者: Zhang, Yan-Yan1, 2;  Yang, Ling1
关键词: cytochrome P450 ;  drug interactions ;  ginsenosides ;  inhibition ;  metabolic stability ;  microsomes ;  steroid ;  traditional Chinese medicine
刊名: EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
发表日期: 2009-06-01
DOI: 10.1517/17425250902967648
卷: 5, 期:6, 页:621-629
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemistry & Molecular Biology ;  Pharmacology & Pharmacy
研究领域[WOS]: Biochemistry & Molecular Biology ;  Pharmacology & Pharmacy
英文摘要: Background: Steroids are groups of biologically active molecules with a wide variety of physiological and pharmacological functions. Human cytochrome P450 (CYP) enzymes present in probably every tissue are found responsible for biosynthesis and catabolism of steroids, which could result in either active or inactive metabolites. In addition, exposure to endogenous and exogenous steroids that causes modulation of CYP activities may substantially affect the pharmacokinetic behavior of a given drug. Objective: This article summarizes our current understanding of the ability of steroids to act as substrates, inhibitors or heteroactivators for human CYP enzymes, with a specific focus on their functional consequences. Methods: in the current review, we compare the mechanisms and regulation of CYP-mediated biotransformation of steroids, and in particular examine the diverse tissue distributions and biological roles of individual CYPs. Conclusion: Metabolic instability of steroids in the presence of CYPs not only affects the magnitude and duration of their actions but may also alter the profiles of their physiological, pathological, pharmacological and toxicological effects in relevant organs.
关键词[WOS]: MECHANISM-BASED INACTIVATION ;  HUMAN LIVER-MICROSOMES ;  CYCLOSPORINE-A OXIDASE ;  MEDROXYPROGESTERONE ACETATE ;  ENDOGENOUS STEROIDS ;  CATALYTIC-ACTIVITY ;  DRUG-INTERACTIONS ;  SACCHAROMYCES-CEREVISIAE ;  SUBSTRATE-SPECIFICITY ;  TISSUE DISTRIBUTION
语种: 英语
WOS记录号: WOS:000267298000004
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141439
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China

Recommended Citation:
Zhang, Yan-Yan,Yang, Ling. Interactions between human cytochrome P450 enzymes and steroids: physiological and pharmacological implications[J]. EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY,2009,5(6):621-629.
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