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Interactions between human cytochrome P450 enzymes and steroids: physiological and pharmacological implications
Zhang, Yan-Yan1,2; Yang, Ling1
KeywordCytochrome P450 Drug Interactions Ginsenosides Inhibition Metabolic Stability Microsomes Steroid Traditional Chinese Medicine
Source PublicationEXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
2009-06-01
DOI10.1517/17425250902967648
Volume5Issue:6Pages:621-629
Indexed BySCI
SubtypeReview
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectBiochemistry & Molecular Biology ; Pharmacology & Pharmacy
WOS Research AreaBiochemistry & Molecular Biology ; Pharmacology & Pharmacy
WOS KeywordMECHANISM-BASED INACTIVATION ; HUMAN LIVER-MICROSOMES ; CYCLOSPORINE-A OXIDASE ; MEDROXYPROGESTERONE ACETATE ; ENDOGENOUS STEROIDS ; CATALYTIC-ACTIVITY ; DRUG-INTERACTIONS ; SACCHAROMYCES-CEREVISIAE ; SUBSTRATE-SPECIFICITY ; TISSUE DISTRIBUTION
AbstractBackground: Steroids are groups of biologically active molecules with a wide variety of physiological and pharmacological functions. Human cytochrome P450 (CYP) enzymes present in probably every tissue are found responsible for biosynthesis and catabolism of steroids, which could result in either active or inactive metabolites. In addition, exposure to endogenous and exogenous steroids that causes modulation of CYP activities may substantially affect the pharmacokinetic behavior of a given drug. Objective: This article summarizes our current understanding of the ability of steroids to act as substrates, inhibitors or heteroactivators for human CYP enzymes, with a specific focus on their functional consequences. Methods: in the current review, we compare the mechanisms and regulation of CYP-mediated biotransformation of steroids, and in particular examine the diverse tissue distributions and biological roles of individual CYPs. Conclusion: Metabolic instability of steroids in the presence of CYPs not only affects the magnitude and duration of their actions but may also alter the profiles of their physiological, pathological, pharmacological and toxicological effects in relevant organs.
Language英语
WOS IDWOS:000267298000004
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/141439
Collection中国科学院大连化学物理研究所
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Yan-Yan,Yang, Ling. Interactions between human cytochrome P450 enzymes and steroids: physiological and pharmacological implications[J]. EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY,2009,5(6):621-629.
APA Zhang, Yan-Yan,&Yang, Ling.(2009).Interactions between human cytochrome P450 enzymes and steroids: physiological and pharmacological implications.EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY,5(6),621-629.
MLA Zhang, Yan-Yan,et al."Interactions between human cytochrome P450 enzymes and steroids: physiological and pharmacological implications".EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY 5.6(2009):621-629.
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