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题名: C-7 configuration as one of determinants in taxanes metabolism by human cytochrome P450 enzymes
作者: Zhang, Y. -Y.1, 3;  Liu, Y.1;  Zhang, J. -W.1;  Ge, G. -B.1;  Liu, H. -X.1, 3;  Wang, L. -M.2;  Sun, J.2;  Yang, L.1
关键词: 7-Epi-cephalomannine ;  7-epi-10-deacetyl-paclitaxel ;  paclitaxel ;  cytochrome P450 ;  structure-metabolism relationships ;  metabolism
刊名: XENOBIOTICA
发表日期: 2009-12-01
DOI: 10.3109/00498250903271989
卷: 39, 期:12, 页:903-914
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Pharmacology & Pharmacy ;  Toxicology
研究领域[WOS]: Pharmacology & Pharmacy ;  Toxicology
英文摘要: 1. Taxanes exhibit a high tendency to epimerize at C-7 under physiological conditions. This study aimed to investigate the composite effect of C-7 configuration and other substructural elements on the metabolic properties of taxanes. Cephalomannine, 7-epi-cephalomannine, 10-deacetyl-paclitaxel, and 7-epi-10-deacetyl-paclitaxel were chosen as model compounds.
关键词[WOS]: IONIZATION MASS-SPECTROMETRY ;  IN-VITRO METABOLISM ;  LIVER-MICROSOMES ;  PACLITAXEL PHARMACOKINETICS ;  REGIOSELECTIVE METABOLISM ;  CYCLOPHOSPHAMIDE ;  DEGRADATION ;  SPECIFICITY ;  DOCETAXEL ;  SUBSTRATE
语种: 英语
WOS记录号: WOS:000272618900003
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141444
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
2.Dalian Med Univ, Affiliated Hosp 2, Dalian, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China

Recommended Citation:
Zhang, Y. -Y.,Liu, Y.,Zhang, J. -W.,et al. C-7 configuration as one of determinants in taxanes metabolism by human cytochrome P450 enzymes[J]. XENOBIOTICA,2009,39(12):903-914.
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