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Silent Myocardial Ischemia Is Associated With Altered Plasma Phospholipids
Lin, Hailong2; Zhang, Jing2; Gao, Peng1
关键词Myocardial Ischemia Metabolomics Phospholipids
刊名JOURNAL OF CLINICAL LABORATORY ANALYSIS
2009
DOI10.1002/jcla.20288
23期:1页:45-50
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Medical Laboratory Technology
研究领域[WOS]Medical Laboratory Technology
关键词[WOS]CORONARY-ARTERY DISEASE ; COMPUTED-TOMOGRAPHY ; ENDOTHELIAL-CELLS ; CULTURED HUMAN ; HEART-DISEASE ; LYSOPHOSPHATIDYLCHOLINE ; DIAGNOSIS ; METABONOMICS ; SEVERITY
英文摘要Timely and accurate confirmation of the occurrence of silent myocardial ischemia (SMI) is critical both for prevention and therapy management. Metabolomics assay may offer an alternative for SMI differentiation and altered biomolecule discovery in addition to traditional measures. In this study, plasma samples were obtained from 14 diagnosed SMI subjects and 25 healthy controls and analyzed by liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry in view of metabolomics. Obtained data were subjected to orthogonal signal correction partial least-squares discriminate analysis. Multivariate statistic analysis indicated a clear separation between the two studied groups. Plasma concentration fluctuation of four kinds of phospholipids showed tight relationship with the occurrence of SMI, among which 1-linoleoylglycerophosphocholine (C18:2) was decreased statistically in SMI population (P = 0.01). The plasma phospholipids' changes were before enzymatic alteration in SMI, which might be a useful complementary reference to facilitate SMI diagnosis. J. Clin. Lab. Anal. 23 : 45-50, 2009. (C) 2009 Wiley-Liss, Inc.
语种英语
WOS记录号WOS:000263135500009
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被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/141456
专题中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China
2.Dalian Municipal Cent Hosp, Div Cardiol, Dalian, Peoples R China
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Lin, Hailong,Zhang, Jing,Gao, Peng. Silent Myocardial Ischemia Is Associated With Altered Plasma Phospholipids[J]. JOURNAL OF CLINICAL LABORATORY ANALYSIS,2009,23(1):45-50.
APA Lin, Hailong,Zhang, Jing,&Gao, Peng.(2009).Silent Myocardial Ischemia Is Associated With Altered Plasma Phospholipids.JOURNAL OF CLINICAL LABORATORY ANALYSIS,23(1),45-50.
MLA Lin, Hailong,et al."Silent Myocardial Ischemia Is Associated With Altered Plasma Phospholipids".JOURNAL OF CLINICAL LABORATORY ANALYSIS 23.1(2009):45-50.
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