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Silent Myocardial Ischemia Is Associated With Altered Plasma Phospholipids
Lin, Hailong2; Zhang, Jing2; Gao, Peng1
KeywordMyocardial Ischemia Metabolomics Phospholipids
Source PublicationJOURNAL OF CLINICAL LABORATORY ANALYSIS
2009
DOI10.1002/jcla.20288
Volume23Issue:1Pages:45-50
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectMedical Laboratory Technology
WOS Research AreaMedical Laboratory Technology
WOS KeywordCORONARY-ARTERY DISEASE ; COMPUTED-TOMOGRAPHY ; ENDOTHELIAL-CELLS ; CULTURED HUMAN ; HEART-DISEASE ; LYSOPHOSPHATIDYLCHOLINE ; DIAGNOSIS ; METABONOMICS ; SEVERITY
AbstractTimely and accurate confirmation of the occurrence of silent myocardial ischemia (SMI) is critical both for prevention and therapy management. Metabolomics assay may offer an alternative for SMI differentiation and altered biomolecule discovery in addition to traditional measures. In this study, plasma samples were obtained from 14 diagnosed SMI subjects and 25 healthy controls and analyzed by liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry in view of metabolomics. Obtained data were subjected to orthogonal signal correction partial least-squares discriminate analysis. Multivariate statistic analysis indicated a clear separation between the two studied groups. Plasma concentration fluctuation of four kinds of phospholipids showed tight relationship with the occurrence of SMI, among which 1-linoleoylglycerophosphocholine (C18:2) was decreased statistically in SMI population (P = 0.01). The plasma phospholipids' changes were before enzymatic alteration in SMI, which might be a useful complementary reference to facilitate SMI diagnosis. J. Clin. Lab. Anal. 23 : 45-50, 2009. (C) 2009 Wiley-Liss, Inc.
Language英语
WOS IDWOS:000263135500009
Citation statistics
Cited Times:20[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/141456
Collection中国科学院大连化学物理研究所
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China
2.Dalian Municipal Cent Hosp, Div Cardiol, Dalian, Peoples R China
Recommended Citation
GB/T 7714
Lin, Hailong,Zhang, Jing,Gao, Peng. Silent Myocardial Ischemia Is Associated With Altered Plasma Phospholipids[J]. JOURNAL OF CLINICAL LABORATORY ANALYSIS,2009,23(1):45-50.
APA Lin, Hailong,Zhang, Jing,&Gao, Peng.(2009).Silent Myocardial Ischemia Is Associated With Altered Plasma Phospholipids.JOURNAL OF CLINICAL LABORATORY ANALYSIS,23(1),45-50.
MLA Lin, Hailong,et al."Silent Myocardial Ischemia Is Associated With Altered Plasma Phospholipids".JOURNAL OF CLINICAL LABORATORY ANALYSIS 23.1(2009):45-50.
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