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题名: Silent Myocardial Ischemia Is Associated With Altered Plasma Phospholipids
作者: Lin, Hailong2;  Zhang, Jing2;  Gao, Peng1
关键词: myocardial ischemia ;  metabolomics ;  phospholipids
刊名: JOURNAL OF CLINICAL LABORATORY ANALYSIS
发表日期: 2009
DOI: 10.1002/jcla.20288
卷: 23, 期:1, 页:45-50
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Medical Laboratory Technology
研究领域[WOS]: Medical Laboratory Technology
英文摘要: Timely and accurate confirmation of the occurrence of silent myocardial ischemia (SMI) is critical both for prevention and therapy management. Metabolomics assay may offer an alternative for SMI differentiation and altered biomolecule discovery in addition to traditional measures. In this study, plasma samples were obtained from 14 diagnosed SMI subjects and 25 healthy controls and analyzed by liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry in view of metabolomics. Obtained data were subjected to orthogonal signal correction partial least-squares discriminate analysis. Multivariate statistic analysis indicated a clear separation between the two studied groups. Plasma concentration fluctuation of four kinds of phospholipids showed tight relationship with the occurrence of SMI, among which 1-linoleoylglycerophosphocholine (C18:2) was decreased statistically in SMI population (P = 0.01). The plasma phospholipids' changes were before enzymatic alteration in SMI, which might be a useful complementary reference to facilitate SMI diagnosis. J. Clin. Lab. Anal. 23 : 45-50, 2009. (C) 2009 Wiley-Liss, Inc.
关键词[WOS]: CORONARY-ARTERY DISEASE ;  COMPUTED-TOMOGRAPHY ;  ENDOTHELIAL-CELLS ;  CULTURED HUMAN ;  HEART-DISEASE ;  LYSOPHOSPHATIDYLCHOLINE ;  DIAGNOSIS ;  METABONOMICS ;  SEVERITY
语种: 英语
WOS记录号: WOS:000263135500009
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141456
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China
2.Dalian Municipal Cent Hosp, Div Cardiol, Dalian, Peoples R China

Recommended Citation:
Lin, Hailong,Zhang, Jing,Gao, Peng. Silent Myocardial Ischemia Is Associated With Altered Plasma Phospholipids[J]. JOURNAL OF CLINICAL LABORATORY ANALYSIS,2009,23(1):45-50.
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