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题名: "One-Pot" Process for Fabrication of Organic-Silica Hybrid Monolithic Capillary Columns Using Organic Monomer and Alkoxysilane
作者: Wu, Minghuo1;  Wu, Ren'an1;  Wang, Fangjun1;  Ren, Lianbing2;  Dong, Jing1;  Liu, Zhen2;  Zou, Hanfa1
刊名: ANALYTICAL CHEMISTRY
发表日期: 2009-05-01
DOI: 10.1021/ac9000749
卷: 81, 期:9, 页:3529-3536
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: A "one-pot" process for the preparation of organic-silica hybrid capillary monolithic columns by concurrently using organic monomers and alkoxysilanes was described. In this process, the hydrolyzed alkoxysilanes of tetramethoxysilane (TMOS) and vinyltrimethoxysilane (VTMS) as precursors for the synthesis of a silica.-based monolith using the sol-gel method and the organic monomer (allyldimethyldodecylammonium bromide (ADDAB) or acrylamide (AA)) with vinyl groups for free radical polymerization along with the initiator of azobisisobutyronitrile (AIBN) were concurrently introduced into a pretreated capillary; after that, the polycondensation of alkoxysilanes and the copolymerization of organic monomers and as-precondensed siloxanes were subsequently carried out within the confines of a capillary at the proper reaction conditions. Two types of organic-silica hybrid capillary monolithic columns with hydrophobic and hydrophilic properties have been fabricated, respectively, by this "onepot" process using two different organic monomers of ADDAB and AA. The morphologies of the synthesized organic-silica hybrid monolithic columns were characterized by scanning electron microscopy (SEIM). The performances of these organic-silica monolithic columns were investigated by capillary electrochromatography (CEC). The retention behaviors of the neutral and polar compounds on the resulting hydrophobic and hydrophilic organic-silica hybrid monolithic columns confirmed the successful incorporation of organic monomers in the silica monolithic matrix. In addition, the JWDA-silica hybrid capillary monolithic column was also applied in the analysis of tryptic-digests of bovine serum albumin (BSA) and mouse liver extract by microliquid chromatography-tandem mass spectrometry (mu LC-MS/MS) for demonstrating its potential in proteome analysis.
关键词[WOS]: PERFORMANCE LIQUID-CHROMATOGRAPHY ;  STATIONARY PHASES ;  PROTEOME ANALYSIS ;  HIGH-EFFICIENCY ;  ELECTROCHROMATOGRAPHY ;  IMPROVEMENT ;  SEPARATION ;  FLOW
语种: 英语
WOS记录号: WOS:000265632400045
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141457
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China
2.Nanjing Univ, Sch Chem & Chem Engn, Key Lab Analyt Chem Life Sci, Nanjing 210093, Peoples R China

Recommended Citation:
Wu, Minghuo,Wu, Ren'an,Wang, Fangjun,et al. "One-Pot" Process for Fabrication of Organic-Silica Hybrid Monolithic Capillary Columns Using Organic Monomer and Alkoxysilane[J]. ANALYTICAL CHEMISTRY,2009,81(9):3529-3536.
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