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题名: Systematic screening and characterization of tertiary and quaternary alkaloids from corydalis yanhusuo W.T. Wang using ultra-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry
作者: Zhang, Jing1;  Jin, Yu2;  Dong, Jun1;  Xiao, Yuansheng1;  Feng, Jiatao1;  Xue, Xingya1;  Zhang, Xiuli1;  Liang, Xinmiao1
关键词: UPLC/Q-TOF ;  MS/MS ;  Screening ;  Alkaloids ;  Corydalis yanhusuo WT Wang
刊名: TALANTA
发表日期: 2009-04-30
DOI: 10.1016/j.talanta.2008.12.002
卷: 78, 期:2, 页:513-522
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: Ultra-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry (UPLC-Q-TOF-MS) is an effective technique for analysis of complex samples with offering rapid efficient separation. in combination with accurate mass measurement and tandem mass spectrometry (MS/MS) This a er exploits this technique to identify the alkaloids in corydalis yanhusuo, an important antalgic Traditional Chinese Medicine (TCM). The mass spectral fragmentation behavior of one tertiary alkaloid and two quaternary alkaloids was studied in detail. Low-abundance product ions of tertiary and quaternary alkaloids were investigated and compared between each other. Sixteen alkaloids were screened out by using a systematic screening method developed in our laboratory; structures of eight therein were identified by characteristic UV absorption spectrum and positive ion mode of Q-TOF-MS/MS; and two of them were discovered for the first time in corydalis yanhusuo to our knowledge. This research demonstrates the potential of UPLC-Q-TOF-MS in structural characterization and identification of components in traditional Chinese herbal medicines. (C) 2008 Elsevier B.V. All rights reserved.
关键词[WOS]: TETRAHYDROPALMATINE ;  PROTOBERBERINE ;  IDENTIFICATION ;  SEPARATION ;  EXTRACT ;  MS
语种: 英语
WOS记录号: WOS:000264043400028
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141475
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

Recommended Citation:
Zhang, Jing,Jin, Yu,Dong, Jun,et al. Systematic screening and characterization of tertiary and quaternary alkaloids from corydalis yanhusuo W.T. Wang using ultra-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry[J]. TALANTA,2009,78(2):513-522.
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