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题名: RACK1 associates with CLEC-2 and promotes its ubiquitin-proteasome degradation
作者: Ruan, Yuanyuan1;  Guo, Liang1;  Qiao, Ying2;  Hong, Yi1;  Zhou, Lei1;  Sun, Linlin1;  Wang, Lijing1;  Zhu, Haiyan1;  Wang, Lan1;  Yun, Xiaojing1;  Xie, Jianhui1;  Gu, Jianxin1
关键词: CLEC-2 ;  RACK1 ;  Ubiquitination ;  Degradation
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2009-12-11
DOI: 10.1016/j.bbrc.2009.09.087
卷: 390, 期:2, 页:217-222
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemistry & Molecular Biology ;  Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ;  Biophysics
英文摘要: CLEC-2 is a C-type lectin-like receptor and plays an important role in platelet activation. Snake venom toxin rhodocytin and the endogenous sialoglycoprotein podoplanin are identified as ligands for CLEC-2 and function as stimulators in platelet activation. We also previously indentified two splice variants of murine CLEC-2 as well as a soluble fragment cleaved from the full-length form. However, little is known about the interacting partners with the cytoplasmic region of CLEC-2. In this Study, we reported that RACK1, the receptor for activated C-kinase 1, associated with the cytoplasmic tail of CLEC-2. Moreover, overexpression of RACK 1 decreased the stability of CLEC-2 through promoting its ubiquitin-proteasome degradation, without impairing surface expression and downstream signaling of CLEC-2. Taken together, these results suggest RACK1 as a novel modulator of CLEC-2 expression. (C) 2009 Elsevier Inc. All rights reserved.
关键词[WOS]: MOLECULAR CHARACTERIZATION ;  PLATELET ACTIVATION ;  RECEPTOR CLEC-2 ;  CANCER-CELLS ;  DC-SIGN ;  PROTEIN ;  MEDIATE
语种: 英语
WOS记录号: WOS:000271552400009
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141483
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Fudan Univ, Shanghai Med Coll, Ctr Gene Res, Shanghai 200032, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Recommended Citation:
Ruan, Yuanyuan,Guo, Liang,Qiao, Ying,et al. RACK1 associates with CLEC-2 and promotes its ubiquitin-proteasome degradation[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2009,390(2):217-222.
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