DICP OpenIR
RACK1 associates with CLEC-2 and promotes its ubiquitin-proteasome degradation
Ruan, Yuanyuan1; Guo, Liang1; Qiao, Ying2; Hong, Yi1; Zhou, Lei1; Sun, Linlin1; Wang, Lijing1; Zhu, Haiyan1; Wang, Lan1; Yun, Xiaojing1; Xie, Jianhui1; Gu, Jianxin1
KeywordClec-2 Rack1 Ubiquitination Degradation
Source PublicationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2009-12-11
DOI10.1016/j.bbrc.2009.09.087
Volume390Issue:2Pages:217-222
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectBiochemistry & Molecular Biology ; Biophysics
WOS Research AreaBiochemistry & Molecular Biology ; Biophysics
WOS KeywordMOLECULAR CHARACTERIZATION ; PLATELET ACTIVATION ; RECEPTOR CLEC-2 ; CANCER-CELLS ; DC-SIGN ; PROTEIN ; MEDIATE
AbstractCLEC-2 is a C-type lectin-like receptor and plays an important role in platelet activation. Snake venom toxin rhodocytin and the endogenous sialoglycoprotein podoplanin are identified as ligands for CLEC-2 and function as stimulators in platelet activation. We also previously indentified two splice variants of murine CLEC-2 as well as a soluble fragment cleaved from the full-length form. However, little is known about the interacting partners with the cytoplasmic region of CLEC-2. In this Study, we reported that RACK1, the receptor for activated C-kinase 1, associated with the cytoplasmic tail of CLEC-2. Moreover, overexpression of RACK 1 decreased the stability of CLEC-2 through promoting its ubiquitin-proteasome degradation, without impairing surface expression and downstream signaling of CLEC-2. Taken together, these results suggest RACK1 as a novel modulator of CLEC-2 expression. (C) 2009 Elsevier Inc. All rights reserved.
Language英语
WOS IDWOS:000271552400009
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/141483
Collection中国科学院大连化学物理研究所
Affiliation1.Fudan Univ, Shanghai Med Coll, Ctr Gene Res, Shanghai 200032, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Ruan, Yuanyuan,Guo, Liang,Qiao, Ying,et al. RACK1 associates with CLEC-2 and promotes its ubiquitin-proteasome degradation[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2009,390(2):217-222.
APA Ruan, Yuanyuan.,Guo, Liang.,Qiao, Ying.,Hong, Yi.,Zhou, Lei.,...&Gu, Jianxin.(2009).RACK1 associates with CLEC-2 and promotes its ubiquitin-proteasome degradation.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,390(2),217-222.
MLA Ruan, Yuanyuan,et al."RACK1 associates with CLEC-2 and promotes its ubiquitin-proteasome degradation".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 390.2(2009):217-222.
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