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题名: Tetramethylpyrazine suppresses interleukin-8 expression in LPS-stimulated human umbilical vein endothelial cell by blocking ERK, p38 and nulear factor-kappa B signaling pathways
作者: Li, Xiu-Ying1;  He, Jun-Lin2;  Liu, Hong-Tao1, 3;  Li, Wen-Ming1;  Yu, Chao1
关键词: Tetramethylpyrazine ;  Human umbilical vein endothelial cells ;  Interleukin-8 ;  Nulear factor-kappa B ;  MAP kinase
刊名: JOURNAL OF ETHNOPHARMACOLOGY
发表日期: 2009-08-17
DOI: 10.1016/j.jep.2009.06.008
卷: 125, 期:1, 页:83-89
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Plant Sciences ;  Chemistry, Medicinal ;  Integrative & Complementary Medicine ;  Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ;  Pharmacology & Pharmacy ;  Integrative & Complementary Medicine
英文摘要: Aim of the study: To determine the anti-inflammatory effects of Tetramethylpyrazine (TMP) and to investigate the inhibitory effect of TMP on IL-8 production in human umbilical vein endothelial cells (HUVECs) induced by LIPS might be mediated by inhibiting p38, ERK and NF-kappa B signaling pathways.
关键词[WOS]: SMOOTH-MUSCLE-CELLS ;  ANTIPLATELET ACTIVITY ;  GENE-EXPRESSION ;  CORONARY ;  ATHEROSCLEROSIS ;  MACROPHAGES ;  DISEASE ;  IL-8 ;  CHEMOATTRACTANT ;  INFLAMMATION
语种: 英语
WOS记录号: WOS:000269850900012
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141504
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chongqing Med Univ, Inst Life Sci, Chongqing 400016, Peoples R China
2.Chongqing Med Univ, Sch Publ Hlth, Chongqing 400016, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Recommended Citation:
Li, Xiu-Ying,He, Jun-Lin,Liu, Hong-Tao,et al. Tetramethylpyrazine suppresses interleukin-8 expression in LPS-stimulated human umbilical vein endothelial cell by blocking ERK, p38 and nulear factor-kappa B signaling pathways[J]. JOURNAL OF ETHNOPHARMACOLOGY,2009,125(1):83-89.
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