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题名: Evaluation of the interaction of bioactive compounds in Cortex Pseudolarix and Radix Stephaniae by the microdialysis probe coupled with high performance liquid chromatography-mass spectrometry
作者: Lei, Xiaoyuan2;  Kong, Liang1, 2;  Zou, Hanfa2;  Ma, Hong2;  Yang, Ling2
关键词: Biological fingerprinting chromatogram analysis ;  Cortex Pseudolarix ;  Radix Stephaniae ;  MCF-7 ;  Multidrug resistance
刊名: JOURNAL OF CHROMATOGRAPHY A
发表日期: 2009-03-13
DOI: 10.1016/j.chroma.2008.05.068
卷: 1216, 期:11, 页:2179-2184
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: An efficient and convenient method, biological Fingerprinting chromatogram analysis is presented. which is applied to the comparison or finger printing chromatograms of the extracts of Chinese herbal medicines after the interaction with biological systems (cell, DNA, protein, etc.). The method was established for the purpose of screening and analysis of the multiple bioactive compounds in herbal medicines. In this work, microdialysis sampling combined with high performance liquid chromatography-mass spectrometry (HPLC-MS) was Studied for binding property of MCF 7 and multidrug resistant MCF-7 cell systems. The results showed that pseudolaric acid A (PAA) and pseudolaric acid B (PAB) in the cortex of Pseudolarix kaempferi (Lamb.) Gorden can easily bind to the MCF-7 cells ranging from 0 to 16.3% (PAA) and from 0 to 35.7% (PAB), and another compound, tetrandrine (TET) from the root of Stephania tetrandrae S. Moore, showed higher binding activity with multidrug resistant MCF-7 cells ranging from 0 to 39.9%. (C) 2008 Elsevier B.V. All rights reserved.
关键词[WOS]: TRADITIONAL CHINESE MEDICINES ;  GENE-EXPRESSION PATTERNS ;  MULTIDRUG-RESISTANCE ;  DNA ;  MICROARRAY ;  PRODUCTS ;  BINDING ;  PROTEIN ;  CELLS ;  HPLC
语种: 英语
WOS记录号: WOS:000264226500027
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141566
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Dalian Fisheries Univ, Coll Marine Environm Engn, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China

Recommended Citation:
Lei, Xiaoyuan,Kong, Liang,Zou, Hanfa,et al. Evaluation of the interaction of bioactive compounds in Cortex Pseudolarix and Radix Stephaniae by the microdialysis probe coupled with high performance liquid chromatography-mass spectrometry[J]. JOURNAL OF CHROMATOGRAPHY A,2009,1216(11):2179-2184.
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