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Evaluation of the interaction of bioactive compounds in Cortex Pseudolarix and Radix Stephaniae by the microdialysis probe coupled with high performance liquid chromatography-mass spectrometry
Lei, Xiaoyuan2; Kong, Liang1,2; Zou, Hanfa2; Ma, Hong2; Yang, Ling2
关键词Biological Fingerprinting Chromatogram Analysis Cortex Pseudolarix Radix Stephaniae Mcf-7 Multidrug Resistance
刊名JOURNAL OF CHROMATOGRAPHY A
2009-03-13
DOI10.1016/j.chroma.2008.05.068
1216期:11页:2179-2184
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]TRADITIONAL CHINESE MEDICINES ; GENE-EXPRESSION PATTERNS ; MULTIDRUG-RESISTANCE ; DNA ; MICROARRAY ; PRODUCTS ; BINDING ; PROTEIN ; CELLS ; HPLC
英文摘要An efficient and convenient method, biological Fingerprinting chromatogram analysis is presented. which is applied to the comparison or finger printing chromatograms of the extracts of Chinese herbal medicines after the interaction with biological systems (cell, DNA, protein, etc.). The method was established for the purpose of screening and analysis of the multiple bioactive compounds in herbal medicines. In this work, microdialysis sampling combined with high performance liquid chromatography-mass spectrometry (HPLC-MS) was Studied for binding property of MCF 7 and multidrug resistant MCF-7 cell systems. The results showed that pseudolaric acid A (PAA) and pseudolaric acid B (PAB) in the cortex of Pseudolarix kaempferi (Lamb.) Gorden can easily bind to the MCF-7 cells ranging from 0 to 16.3% (PAA) and from 0 to 35.7% (PAB), and another compound, tetrandrine (TET) from the root of Stephania tetrandrae S. Moore, showed higher binding activity with multidrug resistant MCF-7 cells ranging from 0 to 39.9%. (C) 2008 Elsevier B.V. All rights reserved.
语种英语
WOS记录号WOS:000264226500027
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/141566
专题中国科学院大连化学物理研究所
作者单位1.Dalian Fisheries Univ, Coll Marine Environm Engn, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China
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Lei, Xiaoyuan,Kong, Liang,Zou, Hanfa,et al. Evaluation of the interaction of bioactive compounds in Cortex Pseudolarix and Radix Stephaniae by the microdialysis probe coupled with high performance liquid chromatography-mass spectrometry[J]. JOURNAL OF CHROMATOGRAPHY A,2009,1216(11):2179-2184.
APA Lei, Xiaoyuan,Kong, Liang,Zou, Hanfa,Ma, Hong,&Yang, Ling.(2009).Evaluation of the interaction of bioactive compounds in Cortex Pseudolarix and Radix Stephaniae by the microdialysis probe coupled with high performance liquid chromatography-mass spectrometry.JOURNAL OF CHROMATOGRAPHY A,1216(11),2179-2184.
MLA Lei, Xiaoyuan,et al."Evaluation of the interaction of bioactive compounds in Cortex Pseudolarix and Radix Stephaniae by the microdialysis probe coupled with high performance liquid chromatography-mass spectrometry".JOURNAL OF CHROMATOGRAPHY A 1216.11(2009):2179-2184.
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