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题名: Investigation of Propofol Concentrations in Human Breath by Solid-phase Microextraction Gas Chromatography-Mass Spectrometry
作者: Gong, Y.1;  Li, E.1;  Xu, G.2;  Wang, H.1;  Wang, C.1;  Li, P.1;  He, Y.1
关键词: ANAESTHESIA ;  PROPOFOL ;  EXHALED GAS ;  PLASMA ;  SOLID-PHASE MICROEXTRACTION ;  GAS CHROMATOGRAPHY-MASS SPECTROMETRY
刊名: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
发表日期: 2009-09-01
卷: 37, 期:5, 页:1465-1471
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Medicine, Research & Experimental ;  Pharmacology & Pharmacy
研究领域[WOS]: Research & Experimental Medicine ;  Pharmacology & Pharmacy
英文摘要: Propofol has been detected in human breath after being used as an intravenous anaesthetic, and this could provide a noninvasive method for monitoring propofol anaesthesia. The physicochemical properties of propofol allow it to diffuse across the alveolocapillary membrane and to be prepared as a calibration gas. In this study, headspace solid-phase microextraction gas chromatography-mass spectrometry (HS-SPME-GC-MS), coupled with an external standard, was applied to assess propofol levels in the breath and plasma from three subjects under intravenous anaesthesia. Lower quantitation limits were 3.6 ng/l and 0.2 mg/l for propofol analysis in breath and arterial plasma, respectively. Intraday precision and recovery percentages for propofol detection in breath were 4.3 - 6.7% and 98 - 108%, respectively, and in plasma they were 3.8 - 6.1% and 90.1 - 125.1%, respectively. Propofol concentrations were 4.3 - 33.5 ng/l in breath and 3.2 - 6.8 mg/l in arterial plasma. A correlation was shown between propofol concentration in breath and plasma. Thus, HS-SPME-GC-MS, coupled with an external standard, could be a reliable and sensitive analytical technique for detecting propofol in breath during anaesthesia.
关键词[WOS]: ANESTHESIA ;  PLASMA
语种: 英语
WOS记录号: WOS:000273133200022
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141579
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Harbin Med Coll, Dept Anaesthesiol, Affiliated Hosp 1, Harbin 150001, Heilongjiang, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian, Liaoning, Peoples R China

Recommended Citation:
Gong, Y.,Li, E.,Xu, G.,et al. Investigation of Propofol Concentrations in Human Breath by Solid-phase Microextraction Gas Chromatography-Mass Spectrometry[J]. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,2009,37(5):1465-1471.
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