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题名: Optimal control of a batch bioreactor for the production of a novel antifungal substance CF66I
作者: Quan, Chun-Shan1, 2;  Li, Xin3, 4;  Wang, Jun-Hua1, 2;  Zheng, Wei1, 2;  Fan, Sheng-Di1, 2
关键词: Burkholderia cepacia ;  antifungal activity ;  optimal control ;  CF66I
刊名: AFRICAN JOURNAL OF BIOTECHNOLOGY
发表日期: 2009-11-02
卷: 8, 期:21, 页:5702-5710
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biotechnology & Applied Microbiology
研究领域[WOS]: Biotechnology & Applied Microbiology
英文摘要: More than 80% of the plant diseases are caused by fungi. Usually, fungi not only destroy the plants, but also produce mycotoxins that are harmful to human health. At present, chemical fungicides are mainly used for the prevention of fungi-related plant diseases, however, research and development of biological prevention and controlling are of great importance. In this work, the effects of pH and temperature on cell growth and CF66I formation in batch culture of Burkholderia cepecia CF-66 were studied. The pH value has a marked effect on cell growth and production of CF66I. The lag phase was much longer when pH set lower (e.g.5.0) or higher (e.g.8.0). For earlier phase, optimal pH value was 6.0, because the lag phase can be shortened and the whole fermentation phase can also be shorten and then quickly goes into CF66I production phase. In the late phase, the higher pH is in favor of the production of CF66I. Different temperature have different effect on cell yield, specific growth rate, CF66I yield and specific synthesis rate. In the prophase of fermentation, it is better to set higher temperature to make the cell growth maximizing as soon as possible. However in mid-anaphase, lower temperature shortens the fermentation time, reduce heating energy and the cost. According about results, an optimal control strategy was constructed.
关键词[WOS]: BURKHOLDERIA-CEPACIA COMPLEX ;  APHANOMYCES ROOT-ROT ;  PYTHIUM DAMPING-OFF ;  CYSTIC-FIBROSIS PATIENTS ;  PSEUDOMONAS-CEPACIA ;  BIOLOGICAL-CONTROL ;  IDENTIFICATION ;  BIOCONTROL ;  PYRROLNITRIN ;  INHIBITION
语种: 英语
WOS记录号: WOS:000273718700012
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141581
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Dalian Nationalities Univ, Life Sci Coll, Dalian 116600, Peoples R China
2.Dalian Nationalities Univ, Key Lab Biotechnol & Bioresources Utilizat, State Ethn Affairs Commiss & Minist Educ, Dalian 116600, Peoples R China
3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Recommended Citation:
Quan, Chun-Shan,Li, Xin,Wang, Jun-Hua,et al. Optimal control of a batch bioreactor for the production of a novel antifungal substance CF66I[J]. AFRICAN JOURNAL OF BIOTECHNOLOGY,2009,8(21):5702-5710.
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