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Structure Elucidation of Major Metabolites from Medroxyprogesterone Acetate by P450
Chen, Jianjun1; Zhang, Jiang-Wei2; Yang, Ling2; Li, Wei1
关键词Medroxyprogesterone Acetate Metabolite P450 Enzyme Nmr Structure Elucidation
刊名CHEMICAL & PHARMACEUTICAL BULLETIN
2009-08-01
57期:8页:835-839
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
英文摘要We previously reported the separation and identification for the major metabolites from incubating medroxyprogesterone acetate (MPA) with P450. The structure assignments for these metabolites were tentatively assigned based on one-dimensional (1D) proton NMR. Unambiguous structure identification of these metabolites is critical to study biological pathways of P450. Here we report the complete structure elucidation by extensive two-dimensional (2D) NMR for the three major metabolites isolated in our earlier studies. The three major metabolites (namely M-2, M-3, M-4) were unambiguously identified to be 6 beta-, 1 beta-, and 2 beta-hydroxy MPA. The current work confirmed the speculated structures for these metabolites in our previous studies. More importantly, the unambiguous structural information and the establishment for their NMR chemical shifts of these metabolites can serve as reference standards for future studies.
语种英语
WOS记录号WOS:000268547300009
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/141585
专题中国科学院大连化学物理研究所
作者单位1.Univ Tennessee, Ctr Hlth Sci, Coll Pharm, Dept Pharmaceut Sci, Memphis, TN 38163 USA
2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
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GB/T 7714
Chen, Jianjun,Zhang, Jiang-Wei,Yang, Ling,et al. Structure Elucidation of Major Metabolites from Medroxyprogesterone Acetate by P450[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2009,57(8):835-839.
APA Chen, Jianjun,Zhang, Jiang-Wei,Yang, Ling,&Li, Wei.(2009).Structure Elucidation of Major Metabolites from Medroxyprogesterone Acetate by P450.CHEMICAL & PHARMACEUTICAL BULLETIN,57(8),835-839.
MLA Chen, Jianjun,et al."Structure Elucidation of Major Metabolites from Medroxyprogesterone Acetate by P450".CHEMICAL & PHARMACEUTICAL BULLETIN 57.8(2009):835-839.
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