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题名: Structure Elucidation of Major Metabolites from Medroxyprogesterone Acetate by P450
作者: Chen, Jianjun1;  Zhang, Jiang-Wei2;  Yang, Ling2;  Li, Wei1
关键词: Medroxyprogesterone acetate metabolite ;  P450 enzyme ;  NMR structure elucidation
刊名: CHEMICAL & PHARMACEUTICAL BULLETIN
发表日期: 2009-08-01
卷: 57, 期:8, 页:835-839
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Chemistry, Medicinal ;  Chemistry, Multidisciplinary ;  Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy ;  Chemistry
英文摘要: We previously reported the separation and identification for the major metabolites from incubating medroxyprogesterone acetate (MPA) with P450. The structure assignments for these metabolites were tentatively assigned based on one-dimensional (1D) proton NMR. Unambiguous structure identification of these metabolites is critical to study biological pathways of P450. Here we report the complete structure elucidation by extensive two-dimensional (2D) NMR for the three major metabolites isolated in our earlier studies. The three major metabolites (namely M-2, M-3, M-4) were unambiguously identified to be 6 beta-, 1 beta-, and 2 beta-hydroxy MPA. The current work confirmed the speculated structures for these metabolites in our previous studies. More importantly, the unambiguous structural information and the establishment for their NMR chemical shifts of these metabolites can serve as reference standards for future studies.
语种: 英语
WOS记录号: WOS:000268547300009
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141585
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Univ Tennessee, Ctr Hlth Sci, Coll Pharm, Dept Pharmaceut Sci, Memphis, TN 38163 USA
2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China

Recommended Citation:
Chen, Jianjun,Zhang, Jiang-Wei,Yang, Ling,et al. Structure Elucidation of Major Metabolites from Medroxyprogesterone Acetate by P450[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2009,57(8):835-839.
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