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Structure Elucidation of Major Metabolites from Medroxyprogesterone Acetate by P450
Chen, Jianjun1; Zhang, Jiang-Wei2; Yang, Ling2; Li, Wei1
KeywordMedroxyprogesterone Acetate Metabolite P450 Enzyme Nmr Structure Elucidation
Source PublicationCHEMICAL & PHARMACEUTICAL BULLETIN
2009-08-01
Volume57Issue:8Pages:835-839
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectChemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
WOS Research AreaPharmacology & Pharmacy ; Chemistry
AbstractWe previously reported the separation and identification for the major metabolites from incubating medroxyprogesterone acetate (MPA) with P450. The structure assignments for these metabolites were tentatively assigned based on one-dimensional (1D) proton NMR. Unambiguous structure identification of these metabolites is critical to study biological pathways of P450. Here we report the complete structure elucidation by extensive two-dimensional (2D) NMR for the three major metabolites isolated in our earlier studies. The three major metabolites (namely M-2, M-3, M-4) were unambiguously identified to be 6 beta-, 1 beta-, and 2 beta-hydroxy MPA. The current work confirmed the speculated structures for these metabolites in our previous studies. More importantly, the unambiguous structural information and the establishment for their NMR chemical shifts of these metabolites can serve as reference standards for future studies.
Language英语
WOS IDWOS:000268547300009
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/141585
Collection中国科学院大连化学物理研究所
Affiliation1.Univ Tennessee, Ctr Hlth Sci, Coll Pharm, Dept Pharmaceut Sci, Memphis, TN 38163 USA
2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Chen, Jianjun,Zhang, Jiang-Wei,Yang, Ling,et al. Structure Elucidation of Major Metabolites from Medroxyprogesterone Acetate by P450[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2009,57(8):835-839.
APA Chen, Jianjun,Zhang, Jiang-Wei,Yang, Ling,&Li, Wei.(2009).Structure Elucidation of Major Metabolites from Medroxyprogesterone Acetate by P450.CHEMICAL & PHARMACEUTICAL BULLETIN,57(8),835-839.
MLA Chen, Jianjun,et al."Structure Elucidation of Major Metabolites from Medroxyprogesterone Acetate by P450".CHEMICAL & PHARMACEUTICAL BULLETIN 57.8(2009):835-839.
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