DICP OpenIR
Synthesis and application of photoaffinity probe containing an intact isoprenoid chain
Li, Lingdong1,2; Tang, Wei1,2; Zhao, Zongbao Kent1
KeywordIsoprenoid Chain Chemical Probe Photoaffinity Labeling Streptavidin Blot
Source PublicationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2009-08-15
DOI10.1016/j.bmcl.2009.06.037
Volume19Issue:16Pages:4824-4826
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectChemistry, Medicinal ; Chemistry, Organic
WOS Research AreaPharmacology & Pharmacy ; Chemistry
WOS KeywordFARNESYL TRANSFERASE ; DIPHOSPHATE ANALOGS ; PROTEIN ; PRENYLTRANSFERASES ; ESTERS ; BIOCHEMISTRY ; INHIBITORS ; ALCOHOLS
AbstractTwo novel chemical probes each carrying an intact isoprenoid chain, a biotin tag and a benzophenone moiety were synthesized. Photoaffinity labeling of the Saccharomyces cerevisiae cell lysate revealed that these probes could selectively trap some proteins, and proteins with molecular weight of similar to 70 KDa appeared as a major band upon Streptavidin blot analysis. (C) 2009 Elsevier Ltd. All rights reserved.
Language英语
WOS IDWOS:000268358800065
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/141588
Collection中国科学院大连化学物理研究所
Affiliation1.CAS, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Li, Lingdong,Tang, Wei,Zhao, Zongbao Kent. Synthesis and application of photoaffinity probe containing an intact isoprenoid chain[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2009,19(16):4824-4826.
APA Li, Lingdong,Tang, Wei,&Zhao, Zongbao Kent.(2009).Synthesis and application of photoaffinity probe containing an intact isoprenoid chain.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,19(16),4824-4826.
MLA Li, Lingdong,et al."Synthesis and application of photoaffinity probe containing an intact isoprenoid chain".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 19.16(2009):4824-4826.
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