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Synthesis and application of photoaffinity probe containing an intact isoprenoid chain
Li, Lingdong1,2; Tang, Wei1,2; Zhao, Zongbao Kent1
关键词Isoprenoid Chain Chemical Probe Photoaffinity Labeling Streptavidin Blot
刊名BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2009-08-15
DOI10.1016/j.bmcl.2009.06.037
19期:16页:4824-4826
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]FARNESYL TRANSFERASE ; DIPHOSPHATE ANALOGS ; PROTEIN ; PRENYLTRANSFERASES ; ESTERS ; BIOCHEMISTRY ; INHIBITORS ; ALCOHOLS
英文摘要Two novel chemical probes each carrying an intact isoprenoid chain, a biotin tag and a benzophenone moiety were synthesized. Photoaffinity labeling of the Saccharomyces cerevisiae cell lysate revealed that these probes could selectively trap some proteins, and proteins with molecular weight of similar to 70 KDa appeared as a major band upon Streptavidin blot analysis. (C) 2009 Elsevier Ltd. All rights reserved.
语种英语
WOS记录号WOS:000268358800065
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/141588
专题中国科学院大连化学物理研究所
作者单位1.CAS, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
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Li, Lingdong,Tang, Wei,Zhao, Zongbao Kent. Synthesis and application of photoaffinity probe containing an intact isoprenoid chain[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2009,19(16):4824-4826.
APA Li, Lingdong,Tang, Wei,&Zhao, Zongbao Kent.(2009).Synthesis and application of photoaffinity probe containing an intact isoprenoid chain.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,19(16),4824-4826.
MLA Li, Lingdong,et al."Synthesis and application of photoaffinity probe containing an intact isoprenoid chain".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 19.16(2009):4824-4826.
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