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题名: Synthesis and application of photoaffinity probe containing an intact isoprenoid chain
作者: Li, Lingdong1, 2;  Tang, Wei1, 2;  Zhao, Zongbao Kent1
关键词: Isoprenoid chain ;  Chemical probe ;  Photoaffinity labeling ;  Streptavidin blot
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
发表日期: 2009-08-15
DOI: 10.1016/j.bmcl.2009.06.037
卷: 19, 期:16, 页:4824-4826
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Chemistry, Medicinal ;  Chemistry, Organic
研究领域[WOS]: Pharmacology & Pharmacy ;  Chemistry
英文摘要: Two novel chemical probes each carrying an intact isoprenoid chain, a biotin tag and a benzophenone moiety were synthesized. Photoaffinity labeling of the Saccharomyces cerevisiae cell lysate revealed that these probes could selectively trap some proteins, and proteins with molecular weight of similar to 70 KDa appeared as a major band upon Streptavidin blot analysis. (C) 2009 Elsevier Ltd. All rights reserved.
关键词[WOS]: FARNESYL TRANSFERASE ;  DIPHOSPHATE ANALOGS ;  PROTEIN ;  PRENYLTRANSFERASES ;  ESTERS ;  BIOCHEMISTRY ;  INHIBITORS ;  ALCOHOLS
语种: 英语
WOS记录号: WOS:000268358800065
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141588
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.CAS, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

Recommended Citation:
Li, Lingdong,Tang, Wei,Zhao, Zongbao Kent. Synthesis and application of photoaffinity probe containing an intact isoprenoid chain[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2009,19(16):4824-4826.
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