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题名: Enantioselective Rh-Catalyzed Hydrogenation of 3-Aryl-4-phosphonobutenoates with a P-Stereogenic BoPhoz-Type Ligand
作者: Duan, Zheng-Chao1, 2;  Hu, Xiang-Ping1;  Zhang, Cheng1, 2;  Zheng, Zhuo1
刊名: JOURNAL OF ORGANIC CHEMISTRY
发表日期: 2010-12-03
DOI: 10.1021/jo101849b
卷: 75, 期:23, 页:8319-8321
收录类别: SCI ;  IC ;  CCR
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
英文摘要: A series of chiral 3-aryl-4-phosphonobutyric acid esters were synthesized in high enantioselectivities (93-98% ee) via the Rh-catalyzed asymmetric hydrogenation of the corresponding 3-aryl-4-phosphonobutenoates using a P-stereogenic BoPhoz-type phosphine-aminophosphine ligand. The methodology has been successfully applied to the asymmetric synthesis of a potential GABA(B) antagonist, (R)-phaclofen, in high enantioselectivity.
关键词[WOS]: PHOSPHINE-PHOSPHORAMIDITE LIGANDS ;  PHOSPHONIC ACID-DERIVATIVES ;  ENOL ESTER PHOSPHONATES ;  CHIRAL ALPHA-ARYL ;  ASYMMETRIC HYDROGENATION ;  ALPHA,BETA-UNSATURATED PHOSPHONATES ;  SUBSTITUTED ETHYLPHOSPHONATES ;  AMINOPHOSPHINE LIGANDS ;  DIPHOSPHINE LIGANDS ;  PRACTICAL LIGANDS
语种: 英语
WOS记录号: WOS:000284519900041
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141656
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

Recommended Citation:
Duan, Zheng-Chao,Hu, Xiang-Ping,Zhang, Cheng,et al. Enantioselective Rh-Catalyzed Hydrogenation of 3-Aryl-4-phosphonobutenoates with a P-Stereogenic BoPhoz-Type Ligand[J]. JOURNAL OF ORGANIC CHEMISTRY,2010,75(23):8319-8321.
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